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Articles Published Processes
5/26/2021 9:58:01 AM | Browse: 402 | Download: 975
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Received |
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2021-01-10 14:10 |
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Peer-Review Started |
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2021-01-10 14:10 |
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To Make the First Decision |
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Return for Revision |
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2021-02-11 18:20 |
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Revised |
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2021-02-21 17:03 |
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Second Decision |
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2021-04-02 06:33 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-04-02 19:51 |
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Articles in Press |
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2021-04-02 19:51 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2021-04-13 02:50 |
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Typeset the Manuscript |
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2021-05-19 03:28 |
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Publish the Manuscript Online |
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2021-05-26 09:58 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Case Report |
| Article Title |
Acute liver failure with thrombotic microangiopathy due to sodium valproate toxicity: A case report
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xuan Mei, Hai-Cong Wu, Mei Ruan and Li-Rong Cai |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Hai-Cong Wu, MS, Attending Doctor, Department of Hepatobiliary Internal Medicine, The 900th Hospital of PLA Joint Logistics Support Force, No.156 North of West-second Ring Road, Gulou District, Fuzhou 350025, Fujian Province, China. 847614051@qq.com |
| Key Words |
Sodium valproate; Drug-induced liver injury; Thrombotic microangiopathy; Plasma exchange; Organ transplantation; Case report |
| Core Tip |
Sodium valproate is widely used in the treatment of epilepsy in clinical practice although it has potential hepatotoxicity. Herein, we report a case of fatal acute liver failure (ALF) with thrombotic microangiopathy (TMA) caused by sodium valproate treatment. A history of chronic hepatitis B virus or combination therapy with sodium valproate and carbapenem may increase the risk of ALF. The combination therapy of plasma exchange, glucocorticoid, and supportive therapy is essential for TMA. Organ transplantation at the early stage of the disease may be the first choice for critically ill patients. Our case report can facilitate further studies on the diagnosis and therapy for ALF with TMA. |
| Publish Date |
2021-05-26 09:58 |
| Citation |
Mei X, Wu HC, Ruan M, Cai LR. Acute liver failure with thrombotic microangiopathy due to sodium valproate toxicity: A case report. World J Clin Cases 2021; 9(17): 4310-4317 |
| URL |
https://www.wjgnet.com/2307-8960/full/v9/i17/4310.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v9.i17.4310 |
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