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        5/18/2021 11:27:35 AM | Browse: 701 | Download: 1755
    
    
        
        
    
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                    |  | Received |  | 2021-01-10 22:12 | 
    
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                    |  | Peer-Review Started |  | 2021-01-10 22:13 | 
    
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                    |  | To Make the First Decision |  |  | 
    
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                    |  | Return for Revision |  | 2021-02-15 03:37 | 
    
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                    |  | Revised |  | 2021-02-21 01:35 | 
    
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                    |  | Second Decision |  | 2021-04-07 12:44 | 
    
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                    |  | Accepted by Journal Editor-in-Chief |  |  | 
    
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                    |  | Accepted by Executive Editor-in-Chief |  | 2021-04-07 17:21 | 
    
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                    |  | Articles in Press |  | 2021-04-07 17:21 | 
    
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                    |  | Publication Fee Transferred |  |  | 
    
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                    |  | Edit the Manuscript by Language Editor |  | 2021-04-15 18:54 | 
    
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                    |  | Typeset the Manuscript |  | 2021-04-29 07:21 | 
            
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                            |  | Publish the Manuscript Online |  | 2021-05-18 11:27 | 
        
        
            
                | ISSN | 2220-3249 (online) | 
            
                | Open Access | This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ | 
            
                | Copyright | © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. | 
                    
                        | Article Reprints | For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247 | 
            
            
                | Permissions | For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207 | 
            
            
                | Publisher | Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA | 
            
                | Website | http://www.wjgnet.com | 
        
    
        | Category | Endocrinology & Metabolism | 
    
        | Manuscript Type | Evidence-Based Medicine | 
    
        | Article Title | Association between population vitamin D status and SARS-CoV-2 related serious-critical illness and deaths: An ecological integrative approach | 
    
        | Manuscript Source | Unsolicited Manuscript | 
    
        | All Author List | Dimitrios T Papadimitriou, Alexandros K Vassaras and Michael F Holick | 
            
                | ORCID |  | 
    
        | Funding Agency and Grant Number |  | 
    
        | Corresponding Author | Dimitrios T Papadimitriou, MD, MSc, PhD, Director, Director, Pediatric - Adolescent Endocrinology & Diabetes, Athens Medical Center, 58, Kifisias av., Marousi 15125, Greece. info@pedoendo.net | 
    
        | Key Words | COVID-19; SARS-CoV-2; Vitamin D status; Vitamin D concentrations; 25-hydroxyvitamin-D; Immunity | 
    
        | Core Tip | To elucidate the role of vitamin D in the coronavirus disease 2019 (COVID-19) pandemic, we examined associations between published representative and standardized European population vitamin D data and the Worldometer COVID-19 data. Linear regression found no correlation between population vitamin D concentrations and the total cases-recovered/million (M), but negative correlations predicting a reduction of 47%-64%-80% in serious-critical illnesses/M and of 61%-82%-102.4% in deaths/M, further enhanced when adapting for life expectancy by 133-177-221% if 25-hydroxyvitamin-D concentrations reach 100-125-150 nmol/L. Weighted ANOVA/ANCOVA showed a decreasing trend (P < 0.001) evaluating serious-critical/M (r2 = 0.22), and the deaths/M (r2 = 0.629) after controlling for life expectancy (r2 = 0.47), by vitamin D population status, respectively. | 
            
                | Publish Date | 2021-05-18 11:27 | 
    
        | Citation | Papadimitriou DT, Vassaras AK, Holick MF. Association between population vitamin D status and SARS-CoV-2 related serious-critical illness and deaths: An ecological integrative approach. World J Virol 2021; 10(3): 111-129 | 
            
                | URL | https://www.wjgnet.com/2220-3249/full/v10/i3/111.htm | 
            
                | DOI | https://dx.doi.org/10.5501/wjv.v10.i3.111 | 
    
    
        
                
        
     
 
                 
             
         
        
    
        
        
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