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Articles Published Processes
11/26/2021 5:51:27 PM | Browse: 498 | Download: 1255
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Received |
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2021-01-13 03:29 |
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Peer-Review Started |
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2021-01-13 03:31 |
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To Make the First Decision |
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Return for Revision |
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2021-07-14 06:10 |
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Revised |
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2021-08-19 06:17 |
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Second Decision |
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2021-10-29 09:57 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-10-31 18:17 |
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Articles in Press |
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2021-10-31 18:17 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2021-10-19 16:50 |
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Typeset the Manuscript |
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2021-11-21 13:49 |
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Publish the Manuscript Online |
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2021-11-26 17:51 |
| ISSN |
1948-9366 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Observational Study |
| Article Title |
Novel roles of lipopolysaccharide and TLR4/NF-κB signaling pathway in the inflammatory response to liver injury in Budd-Chiari syndrome
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jie Li, Xiao-Ming Chen, Chun-Ze Zhou, Wei-Wei Fang, Wei-Fu Lv and De-Lei Cheng |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Natural Science Foundation Project of Anhui Province |
1708085QH218 |
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| Corresponding Author |
De-Lei Cheng, N/A, N/A, N/A, Department of Interventional Radiology, The First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, No. 218 Jixi Road, Hefei 230001, Anhui Province, China. 39055004@qq.com |
| Key Words |
Budd-Chiari syndrome; Liver injury; Lipopolysaccharide; Nuclear factor-kappa B; Toll-like receptor 4 |
| Core Tip |
Budd-Chiari syndrome (BCS) is an uncommon disorder characterized by obstruction of the hepatic venous outflow. When the liver becomes congested and damaged, liver fibrosis and cirrhosis can occur. In this study, we explored the mechanism involving nuclear factor-kappa B (NF-κB) in BCS-induced liver injury in humans and animal models. Results suggest that LPS level is markedly elevated in BCS, and in turn it activates the TLR4/NF-κB signaling pathway, leading to induction into inflammatory cytokines (tumor necrosis factor-α, interleukin-2, and interferon-γ) in response to BCS-induced liver injury. Importantly, our novel findings indicated that the TLR4/NF-κB signaling pathway could be a potential target for therapeutic interventions. |
| Publish Date |
2021-11-26 17:51 |
| Citation |
Li J, Chen XM, Zhou CZ, Fang WW, Lv WF, Cheng DL. Novel roles of lipopolysaccharide and TLR4/NF-κB signaling pathway in the inflammatory response to liver injury in Budd-Chiari syndrome. World J Gastrointest Surg 2021; 13(11): 1448-1462 |
| URL |
https://www.wjgnet.com/1948-9366/full/v13/i11/1448.htm |
| DOI |
https://dx.doi.org/10.4240/wjgs.v13.i11.1448 |
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