BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
4/20/2021 12:49:50 PM | Browse: 545 | Download: 1538
 |
Received |
|
2021-01-14 00:19 |
|
Peer-Review Started |
|
2021-01-14 00:20 |
|
First Decision by Editorial Office Director |
|
2021-02-15 02:55 |
|
Return for Revision |
|
2021-02-15 02:55 |
|
Revised |
|
2021-03-14 06:49 |
 |
Publication Fee Transferred |
|
|
|
Second Decision by Editor |
|
2021-04-02 12:13 |
|
Second Decision by Editor-in-Chief |
|
|
|
Final Decision by Editorial Office Director |
|
2021-04-05 16:40 |
|
Articles in Press |
|
2021-04-05 16:40 |
|
Edit the Manuscript by Language Editor |
|
|
|
Typeset the Manuscript |
|
2021-04-15 01:41 |
|
Publish the Manuscript Online |
|
2021-04-20 12:49 |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Cytotoxic CD8+ T cells and tissue resident memory cells in colorectal cancer based on microsatellite instability and BRAF status
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
James Wei Tatt Toh, Angela L Ferguson, Kevin J Spring, Hema Mahajan and Umaimainthan Palendira |
| ORCID |
|
| Funding Agency and Grant Number |
|
| Corresponding Author |
James Wei Tatt Toh, BSc, MBBS, Senior Lecturer, Surgeon, Division of Surgery and Anaesthesia, Department of Colorectal Surgery, Westmead Hospital, Cnr Hawkesbury and Darcy Rd, Westmead 2145, NSW, Australia. james.toh@sydney.edu.au |
| Key Words |
Tissue resident memory cells; Resident memory T cells; Colorectal cancer; Microsatellite instability; BRAF; DNA mismatch repair; Immunotherapy; Prognosis |
| Core Tip |
Prior to this study, whether T resident memory (TRM) cells exist in colorectal cancer (CRC) was poorly understood. This study has identified and characterize TRM cells within human CRC. CD8+ TRM cells are found in greater abundance in both high microsatellite instability (MSI-H) BRAF mutant and MSI-H BRAF wild type CRC when compared with their microsatellite stable counterpart. CD8+ TRM may play a role in the immunogenicity in both BRAF mutant and BRAF wild type MSI-H CRC. Further studies should focus on the potential immunogenic qualities of TRM cells and investigate potential immunotherapeutic approaches to improve treatment and survival associated with CRC based on TRM. |
| Publish Date |
2021-04-20 12:49 |
| Citation |
Toh JWT, Ferguson A, Spring KJ, Mahajan H, Palendira U. Cytotoxic CD8+ T cells and tissue resident memory cells in colorectal cancer based on microsatellite instability and BRAF status. World J Clin Oncol 2021; 12(4): 238-248 |
| URL |
https://www.wjgnet.com/2218-4333/full/v12/i4/238.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v12.i4.238 |
All content on this site: Copyright © 1993-2026 Baishideng Publishing Group Inc, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.
