Publication Name	World Journal of Gastroenterology
Manuscript ID	6256
Country	Italy

Received	2013-10-11 15:53
Peer-Review Started	2013-10-12 09:11
To Make the First Decision	2013-10-22 16:47
Return for Revision	2013-10-23 09:54
Revised	2013-11-08 19:19
Second Decision	2013-11-29 11:25
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-11-30 01:29
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-01-20 09:55
Publish the Manuscript Online	2014-03-12 14:46

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Splanchnic vasodilation and hyperdynamic circulatory syndrome in cirrhosis
Manuscript Source	Invited Manuscript
All Author List	Massimo Bolognesi, Marco Di Pascoli, Alberto Verardo and Angelo Gatta
Funding Agency and Grant Number
Corresponding Author	Massimo Bolognesi, MD, PhD, Department of Internal Medicine-DIMED, University of Padua, Azienda Ospedaliera Università di Padova, Clinica Medica 5, Via Giustiniani 2, 35128 Padova, Italy. massimo.bolognesi@unipd.it
Key Words	Portal hypertension; Splanchnic flow; Splenic circulation; Nitric oxide; Autonomic dysfunction; Cirrhosis; Hyperdynamic circulatory syndrome
Core Tip	In cirrhosis, portal hypertension is due to an increase in intrahepatic resistance and splanchnic blood flow. The latter is secondary to arterial splanchnic vasodilatation and the opening of collateral circulation. Though the increase in intrahepatic resistance is the earliest and most important component, at present the only treatment regimes which are available for the control of portal hypertension in cirrhosis, i.e., non-selective beta-blockers, octreotide and terlipressin, act on the splanchnic dynamic component. Thus, understanding the mechanisms that lead to splanchnic vasodilatation and to the hyperdynamic circulatory syndrome is essential for the treatment of the complications of portal hypertension.
Publish Date	2014-03-12 14:46
Citation	Bolognesi M, Di Pascoli M, Verardo A, Gatta A. Splanchnic vasodilation and hyperdynamic circulatory syndrome in cirrhosis. World J Gastroenterol 2014; 20(10): 2555-2563
URL	http://www.wjgnet.com/1007-9327/full/v20/i10/2555.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i10.2555

Full Article (PDF)	WJG-20-2555.pdf
Full Article (Word)	WJG-20-2555.doc
Manuscript File	6256-Review.doc
Answering Reviewers	6256-Answering reviewers.pdf
Copyright License Agreement	6256-Copyright assignment.pdf
Peer-review Report	6256-Peer review(s).pdf
Scientific Editor Work List	6256-Scientific editor work list.doc