| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Immunology |
| Manuscript Type |
Case Report |
| Article Title |
Anti-programmed cell death ligand 1-based immunotherapy in recurrent hepatocellular carcinoma with inferior vena cava tumor thrombus and metastasis: Three case reports
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Shao-Ru Liu, Qing Yan, Hao-Ming Lin, Guang-Zi Shi, Yi Cao, Hong Zeng, Chao Liu and Rui Zhang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| The Special Research Foundation of the National Nature Science Foundation of China |
81972262 |
| The Special Research Foundation of the National Nature Science Foundation of China |
81972255 |
| The Guangdong Basic and Applied Basic Research Foundation |
2018A030313645 |
| The Guangdong Basic and Applied Basic Research Foundation |
2020A1515010117 |
| The Guangdong Basic and Applied Basic Research Foundation |
2016A030313840 |
| Key Laboratory of Malignant Tumor Molecular Mechanism and Translational Medicine of Guangzhou Bureau of Science and Information Technology |
[2013]163 |
| the Key Laboratory of Malignant Tumor Gene Regulation and Target Therapy of Guangdong Higher Education Institutes |
KLB09001 |
| Guangdong Science and Technology Department |
2015B050501004 |
| Guangdong Science and Technology Department |
2017B030314026 |
| Sun Yat-sen University Clinical Research 5010 Program |
2018008 |
|
| Corresponding Author |
Rui Zhang, PhD, Doctor, Doctor, Professor, Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation and Department of Biliary-Pancreatic Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, No. 33 YingFeng Road, Haizhu District, Guangzhou 510288, Guangdong Province, China. zhangr95@mail.sysu.edu.cn |
| Key Words |
Case report; Recurrent hepatocellular carcinoma; Inferior vena cava tumor thrombus; Metastasis; Programmed cell death ligand 1; Immunotherapy |
| Core Tip |
Recurrent hepatocellular carcinoma (HCC) with inferior vena cava tumor thrombus (IVCTT) is a great challenge for oncologists and has a poor prognosis. The safety and efficacy of programmed cell death ligand 1 inhibitors are still unknown. To the best of our knowledge, the first case is the first report of successful treatment of recurrent and metastatic HCC with inferior vena cava tumor thrombus with atezolizumab. We reported two other cases of HCC with IVCTT at the first diagnosis, for which patients were treated with a programmed cell death protein 1 inhibitor after surgery or recurrence, and both patients achieved a good outcome. Anti-programmed cell death ligand 1 therapy in HCC patients with IVCTT and metastasis is associated with relatively good patient outcomes. |
| Publish Date |
2021-07-21 08:24 |
| Citation |
Liu SR, Yan Q, Lin HM, Shi GZ, Cao Y, Zeng H, Liu C, Zhang R. Anti-PD-L1 based immunotherapy in recurrent hepatocellular carcinoma with inferior vena cava tumor thrombus and metastasis: Three case report. World J Clin Cases 2021; 9(21): 5988-5998 |
| URL |
https://www.wjgnet.com/2307-8960/full/v9/i21/5988.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v9.i21.5988 |
