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4/14/2021 7:32:38 AM | Browse: 470 | Download: 827
Publication Name World Journal of Gastroenterology
Manuscript ID 62645
Country/Territory China
Received
2021-01-21 10:26
Peer-Review Started
2021-01-21 10:26
To Make the First Decision
Return for Revision
2021-02-09 18:38
Revised
2021-02-17 00:38
Second Decision
2021-03-12 14:28
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2021-03-13 06:45
Articles in Press
2021-03-13 06:45
Publication Fee Transferred
Edit the Manuscript by Language Editor
2021-03-29 02:37
Typeset the Manuscript
2021-04-13 00:12
Publish the Manuscript Online
2021-04-14 07:32
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Basic Study
Article Title Abelson interactor 1 splice isoform-L plays an anti-oncogenic role in colorectal carcinoma through interactions with WAVE2 and full-length Abelson interactor 1
Manuscript Source Unsolicited Manuscript
All Author List Kun Li, Yi-Fan Peng, Jing-Zhu Guo, Mei Li, Yu Zhang, Jing-Yi Chen, Ting-Ru Lin, Xin Yu and Wei-Dong Yu
ORCID
Author(s) ORCID Number
Kun Li http://orcid.org/0000-0002-1945-0779
Yi-Fan Peng http://orcid.org/0000-0002-6159-6088
Jing-Zhu Guo http://orcid.org/0000-0002-8492-0335
Mei Li http://orcid.org/0000-0001-8010-910X
Yu Zhang http://orcid.org/0000-0002-3461-8453
Jing-Yi Chen http://orcid.org/0000-0002-4174-5207
Ting-Ru Lin http://orcid.org/0000-0003-4686-3250
Xin Yu http://orcid.org/0000-0002-5479-5019
Wei-Dong Yu http://orcid.org/0000-0002-7573-4979
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 30872923
National Natural Science Foundation of China 81672853
Peking University People’s Hospital Scientific Research Development Found RDH2020-11
Corresponding Author Wei-Dong Yu, PhD, Professor, Department of Central Laboratory and Institute of Clinical Molecular Biology, Peking University People's Hospital, No. 11 Xizhimen South Street, Xicheng District, Beijing 100044, China. weidongyu@bjmu.edu.cn
Key Words Colon cancer; Abelson interactor 1 isoform-L; Cell adhesion; Cell migration; WAVE2
Core Tip The purpose of this study was to investigate the role and mechanism of Abelson interactor 1 splice isoform-L (ABI1-SiL) in the metastatic behavior of colorectal carcinoma cells. Our results showed that ABI1-SiL played a key role in cell surface area, adhesion, and migration, but not proliferation and apoptosis in SW480 cells. ABI1-SiL may have anti-oncogenic roles by competitively binding to WAVE2, and directly interacting with phosphorylated and non-phosphorylated ABI1-p65, functioning as a dominant-negative molecule towards ABI1-p65.
Publish Date 2021-04-14 07:32
Citation Li K, Peng YF, Guo JZ, Li M, Zhang Y, Chen JY, Lin TR, Yu X, Yu WD. Abelson interactor 1 splice isoform-L plays an anti-oncogenic role in colorectal carcinoma through interactions with WAVE2 and full-length Abelson interactor 1. World J Gastroenterol 2021; 27(15): 1595-1615
URL https://www.wjgnet.com/1007-9327/full/v27/i15/1595.htm
DOI https://dx.doi.org/10.3748/wjg.v27.i15.1595
Full Article (PDF) WJG-27-1595.pdf
Full Article (Word) WJG-27-1595.docx
Manuscript File 62645_Auto_Edited_WangTQ.docx
Answering Reviewers 62645-Answering reviewers.pdf
Audio Core Tip 62645-Audio core tip.wav
Biostatistics Review Certificate 62645-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 62645-Conflict-of-interest statement.pdf
Copyright License Agreement 62645-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 62645-Grant application form(s).pdf
Institutional Review Board Approval Form or Document 62645-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 62645-Language certificate.pdf
Peer-review Report 62645-Peer-review(s).pdf
Scientific Misconduct Check 62645-Bing-Wang JL-1.jpg
Scientific Misconduct Check 62645-Scientific misconduct check.pdf
Scientific Editor Work List 62645-Scientific editor work list.pdf