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Articles Published Processes
10/12/2021 6:53:35 AM | Browse: 317 | Download: 570
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Received |
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2021-01-14 21:26 |
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Peer-Review Started |
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2021-01-14 21:27 |
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To Make the First Decision |
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Return for Revision |
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2021-03-29 05:42 |
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Revised |
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2021-04-30 20:36 |
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Second Decision |
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2021-09-06 03:01 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-09-06 11:09 |
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Articles in Press |
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2021-09-06 11:09 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2021-10-09 03:14 |
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Publish the Manuscript Online |
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2021-10-12 06:53 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Minireviews |
| Article Title |
Transcription factors specificity protein and nuclear receptor 4A1 in pancreatic cancer
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Stephen Safe, Rupesh Shrestha, Kumaravel Mohankumar, Marcell Howard, Erik Hedrick and Maen Abdelrahim |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Houston Methodist Cancer Center Innovation Award |
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| Corresponding Author |
Stephen Safe, PhD, Full Professor, Department of Veterinary Physiology and Pharmacology, Texas A&M University, 4466 TAMU, College Station, TX 77845, United States. ssafe@cvm.tamu.edu |
| Key Words |
Specificity protein; Nuclear receptor 4A1; Pancreatic cancer; Transcription factors; Ligand inhibitors; Nuclear receptor 4A antagonists |
| Core Tip |
Specificity protein (Sp), transcription factors (TFs), Sp1, Sp3 and Sp4, and nuclear receptor 4A1 (NR4A1, Nur77) are highly expressed in pancreatic cancer cells and tumors. Results of gene silencing studies show that Sp TFs and NR4A1 are pro-oncogenic and regulate pathways/genes associated with cell proliferation, survival and migration/invasion. Bis-indole derived ligands (CDIMs) that bind NR4A1 act as NR4A1 antagonists and we discuss an important mechanism of gene regulation by NR4A1/Sp complexes which can be inhibited by NR4A1 antagonists. |
| Publish Date |
2021-10-12 06:53 |
| Citation |
Safe S, Shrestha R, Mohankumar K, Howard M, Hedrick E, Abdelrahim M. Transcription factors specificity protein and nuclear receptor 4A1 in pancreatic cancer. World J Gastroenterol 2021; 27(38): 6387-6398 |
| URL |
https://www.wjgnet.com/1007-9327/full/v27/i38/6387.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v27.i38.6387 |
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