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Articles Published Processes
5/14/2021 9:21:56 AM | Browse: 633 | Download: 1386
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Received |
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2021-01-22 07:20 |
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Peer-Review Started |
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2021-01-20 12:28 |
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To Make the First Decision |
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Return for Revision |
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2021-02-25 06:22 |
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Revised |
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2021-02-28 21:22 |
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Second Decision |
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2021-03-25 06:42 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-03-25 18:46 |
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Articles in Press |
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2021-03-25 18:46 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2021-04-02 21:45 |
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Typeset the Manuscript |
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2021-04-28 17:12 |
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Publish the Manuscript Online |
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2021-05-14 09:21 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Case Report |
| Article Title |
Liver injury associated with the use of selective androgen receptor modulators and post-cycle therapy: Two case reports and review of literature
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Tomas Koller, Petra Vrbova, Iveta Meciarova, Pavol Molcan, Michal Smitka, Svetlana Adamcova Selcanova and Lubomir Skladany |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Tomas Koller, MD, PhD, Associate Professor, Gastroenterology and Hepatology Subdiv. 5th Department of Internal Medicine, Comenius University Faculty of Medicine, Ruzinovska 6, Bratislava 82606, Slovakia. tomas.koller@fmed.uniba.sk |
| Key Words |
Drug induced liver injury; Ligandrol; Ostarine; Cholestasis; Anabolic substances; Ductopenia; Case report |
| Core Tip |
Ligandrol and ostarine are selective androgen receptor modulators presumably having a favorable side-effect profile. They are often misused by amateur body builders aiming to promote muscle growth. Reports on the toxic effects on organ systems are emerging. We report on the liver injury in two young men who used ligandrol and/or ostarine in addition to other muscle promoting substances known as post cycle therapy. They showed jaundice and fatigue, a mixed type of injury, normal alkaline phosphatase, and high bilirubin and bile acids. Histological evidence showed cholestatic injury, canalicular bile plugs, and ductopenia. The patients recovered only after 3 mo. |
| Publish Date |
2021-05-14 09:21 |
| Citation |
Koller T, Vrbova P, Meciarova I, Molcan P, Smitka M, Adamcova Selcanova S, Skladany L. Liver injury associated with the use of selective androgen receptor modulators and post-cycle therapy: Two case reports and review of literature. World J Clin Cases 2021; 9(16): 4062-4071 |
| URL |
https://www.wjgnet.com/2307-8960/full/v9/i16/4062.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v9.i16.4062 |
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