Publication Name	World Journal of Clinical Cases
Manuscript ID	62783
Country	China

Received	2021-01-18 11:55
Peer-Review Started	2021-01-18 11:57
To Make the First Decision
Return for Revision	2021-02-10 12:42
Revised	2021-02-11 07:51
Second Decision	2021-03-16 12:09
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-03-17 05:54
Articles in Press	2021-03-17 05:54
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-03-29 13:03
Typeset the Manuscript	2021-04-08 04:16
Publish the Manuscript Online	2021-04-29 08:35

ISSN	2307-8960 (online)
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Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Prediction models for the development of hepatocellular carcinoma in chronic hepatitis B patients
Manuscript Source	Invited Manuscript
All Author List	Jiang Guo and Xue-Song Gao
ORCID	Author(s) ORCID Number Jiang Guo http://orcid.org/0000-0001-8297-5458 Xue-Song Gao http://orcid.org/0000-0002-7193-4981
Funding Agency and Grant Number	Funding Agency Grant Number National Science and Technology Major Project of China 2018ZX10715-005-003-002 Health Development and Scientific Research in the Capital 2018-1-2181
Corresponding Author	Xue-Song Gao, MD, PhD, Chief Physician, Department of General Medicine, Beijing Ditan Hospital, Capital Medical University, No. 8 Jingshundong Street, Chaoyang District, Beijing 100015, China. gaoxuesong@ccmu.edu.cn
Key Words	Antiviral agents; Hepatitis B virus; Hepatocellular carcinoma; Liver cirrhosis; Risk factors; Proportional hazards models
Core Tip	Risk scores are useful in estimating hepatocellular carcinoma (HCC) risk in chronic hepatitis B (CHB) patients. While antiviral therapy does not eliminate the risk of hepatitis B virus (HBV)-related HCC, it modifies the natural disease course to reduce the HCC risk. CU-HCC (Chinese University-HCC), GAG-HCC (guide with age, gender, HBV DNA, core promoter mutations and cirrhosis) and REACH-B (risk estimation for HCC in CHB) scores derived from Asian CHB patients were also accurate in treated patients. The PAGE-B (platelet, age, and gender-hepatitis B) score has persistently high predictability for treated Caucasian and Asian patients with different HCC risk profiles.
Publish Date	2021-04-29 08:35
Citation	Guo J, Gao XS. Prediction models for the development of hepatocellular carcinoma in chronic hepatitis B patients. World J Clin Cases 2021; 9(14): 3238-3251
URL	https://www.wjgnet.com/2307-8960/full/v9/i14/3238.htm
DOI	https://dx.doi.org/10.12998/wjcc.v9.i14.3238

Full Article (PDF)	WJCC-9-3238.pdf
Full Article (Word)	WJCC-9-3238.docx
Manuscript File	62783_Auto_Edited_WangTQ.docx
Answering Reviewers	62783-Answering reviewers.pdf
Audio Core Tip	62783-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	62783-Conflict-of-interest statement.pdf
Copyright License Agreement	62783-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	62783-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	62783-Language certificate.pdf
Peer-review Report	62783-Peer-review(s).pdf
Scientific Misconduct Check	62783-Scientific misconduct check.pdf
Scientific Editor Work List	62783-Scientific editor work list.pdf