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Articles Published Processes
6/11/2021 9:22:17 AM | Browse: 308 | Download: 836
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Received |
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2021-01-26 14:56 |
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Peer-Review Started |
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2021-01-26 14:58 |
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To Make the First Decision |
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Return for Revision |
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2021-02-25 04:02 |
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Revised |
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2021-03-11 05:46 |
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Second Decision |
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2021-04-12 12:53 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-04-12 17:26 |
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Articles in Press |
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2021-04-12 17:26 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2021-04-16 01:41 |
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Typeset the Manuscript |
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2021-05-31 11:42 |
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Publish the Manuscript Online |
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2021-06-11 09:22 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Histological transformation of non-small cell lung cancer: Clinical analysis of nine cases
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Cai-Bao Jin and Ling Yang |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Ling Yang, MD, Chief Doctor, Department of Thoracic Oncology, Hubei Cancer Hospital, No. 116 Zhuodaoquan South Road, Wuhan 430000, Hubei Province, China. 348711624@qq.com |
| Key Words |
Histological transformation; Epidermal growth factor receptor tyrosine kinase inhibitors; Non-small cell lung cancer; Tumor re-biopsy; Epidermal growth factor receptor mutation |
| Core Tip |
We retrospectively diagnosed 9 cases of non-small cell lung cancer (SCLC) transforming to SCLC, large-cell neuroendocrine carcinoma or squamous cell carcinoma on re-biopsy after epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs). Tumor re-biopsy should be performed routinely when EGFR-TKI therapy fails in lung cancer patients to avoid ignoring histological transformation and to select a subsequent therapeutic strategy. The plasma pro-gastrin-releasing peptide and NSE levels could be valuable and significant biomarkers to predict histological transformation. The transformed tumor retained the original EGFR mutation, which indicates that histological transformation represents an evolution from the initial tumor. |
| Publish Date |
2021-06-11 09:22 |
| Citation |
Jin CB, Yang L. Histological transformation of non-small cell lung cancer: Clinical analysis of nine cases. World J Clin Cases 2021; 9(18): 4617-4626 |
| URL |
https://www.wjgnet.com/2307-8960/full/v9/i18/4617.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v9.i18.4617 |
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