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Articles Published Processes
3/30/2021 7:03:44 AM | Browse: 523 | Download: 1015
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Received |
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2021-01-23 13:34 |
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Peer-Review Started |
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2021-01-23 13:39 |
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To Make the First Decision |
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Return for Revision |
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2021-02-10 05:40 |
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Revised |
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2021-02-10 12:53 |
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Second Decision |
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2021-03-11 13:23 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-03-12 00:41 |
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Articles in Press |
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2021-03-12 00:41 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2021-03-22 03:24 |
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Publish the Manuscript Online |
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2021-03-30 07:03 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Review |
| Article Title |
Metabolic complications of hepatitis C virus infection
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Rahul Chaudhari, Sherouk Fouda, Ashik Sainu and Joseph M Pappachan |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Joseph M Pappachan, FRCP, MD, Consultant Physician-Scientist, Honorary Research Fellow, Senior Researcher, Department of Endocrinology and Metabolism , Lancashire Teaching Hospitals NHS Trust, Royal Preston Hospital, Preston PR2 9HT, United Kingdom. drpappachan@yahoo.co.in |
| Key Words |
Chronic hepatitis C infection; Insulin resistance; Metabolic syndrome; Cardiovascular diseases; Fatty liver; Diabetes mellitus |
| Core Tip |
Available evidence proves a strong association between hepatitis C virus (HCV) and metabolic complications such as hyperlipidemia, hepatic steatosis, insulin resistance, metabolic syndrome, and diabetes mellitus. De novo development of insulin resistance and hepatic steatosis in chronic HCV infection influences the disease progression in the liver and enhances overall morbidity and mortality. The influence of metabolic diseases on HCV infection can increase disease severity. The interplay between HCV major proteins and the liver-muscle-adipose axis is complex and still not fully elucidated. Coexistence of metabolic diseases such as diabetes mellitus and HCV infection are also known to result in adverse outcomes of both disorders. There is evidence that successful treatment halts the progression of liver disease, but more studies are required on how treatment influences the metabolic manifestations. |
| Publish Date |
2021-03-30 07:03 |
| Citation |
Chaudhari R, Fouda S, Sainu A, Pappachan JM. Metabolic complications of hepatitis C virus infection. World J Gastroenterol 2021; 27(13): 1267-1282 |
| URL |
https://www.wjgnet.com/1007-9327/full/v27/i13/1267.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v27.i13.1267 |
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