Publication Name	World Journal of Clinical Cases
Manuscript ID	63045
Country	Türkiye

Received	2021-01-23 13:08
Peer-Review Started	2021-01-23 13:14
To Make the First Decision
Return for Revision	2021-03-01 09:15
Revised	2021-03-14 01:11
Second Decision	2021-05-26 10:08
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2021-05-26 13:00
Articles in Press	2021-05-26 13:00
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-06-15 12:07
Publish the Manuscript Online	2021-06-24 07:26

ISSN	2307-8960 (online)
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Molecular pathways in viral hepatitis-associated liver carcinogenesis: An update
Manuscript Source	Invited Manuscript
All Author List	Gulsum Ozlem Elpek
ORCID	Author(s) ORCID Number Gulsum Ozlem Elpek http://orcid.org/0000-0002-1237-5454
Funding Agency and Grant Number
Corresponding Author	Gulsum Ozlem Elpek, MD, Professor, Department of Pathology, Akdeniz University Medical School, Dumlupınar Bulvarı, Antalya 07070, Türkiye. elpek@akdeniz.edu.tr
Key Words	Hepatitis B virus; Hepatitis C virus; Hepatocellular carcinoma; Carcinogenesis; Molecular pathways; Viral hepatitis.
Core Tip	Hepatocellular carcinoma remains an aggressive tumor, despite extensive studies on its ontogeny and prognosis. Although the occurrence of this tumor in both hepatitis B virus (HBV) and hepatitis C virus (HCV) backgrounds indicates the effect of persistent inflammation in malignant transformation, the viral effects are not limited to the impaired microenvironment. Recent studies have revealed complex mechanisms that reflect concerted and cumulative effects of chronic inflammation-related alterations, modification of oncogenic pathways (especially tumor suppression, proliferation, and apoptosis), and epigenetic dysregulation driven by both HBV and HCV. In addition, the integration of HBV into host DNA may also affect tumor development and behavior.
Publish Date	2021-06-24 07:26
Citation	Elpek GO. Molecular pathways in viral hepatitis-associated liver carcinogenesis: An update. World J Clin Cases 2021; 9(19): 4890-4917
URL	https://www.wjgnet.com/2307-8960/full/v9/i19/4890.htm
DOI	https://dx.doi.org/10.12998/wjcc.v9.i19.4890

Full Article (PDF)	WJCC-9-4890.pdf
Full Article (Word)	WJCC-9-4890.docx
Manuscript File	63045_Auto_Edited-ZMG.docx
Answering Reviewers	63045-Answering reviewers.pdf
Audio Core Tip	63045-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	63045-Conflict-of-interest statement.pdf
Copyright License Agreement	63045-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	63045-Language certificate.pdf
Peer-review Report	63045-Peer-review(s).pdf
Scientific Misconduct Check	63045-Scientific misconduct check.pdf
Scientific Editor Work List	63045-Scientific editor work list.pdf
CrossCheck Report	63045-CrossCheck report.pdf