Publication Name	World Journal of Gastroenterology
Manuscript ID	6314
Country	Japan

Received	2013-10-13 22:36
Peer-Review Started	2013-10-15 11:53
To Make the First Decision	2014-01-09 18:09
Return for Revision	2014-01-16 22:43
Revised
Second Decision	2014-02-27 11:07
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-02-27 11:57
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-03-26 18:39
Publish the Manuscript Online	2014-04-17 13:27

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Therapeutic response assessment of RFA for HCC: Contrast-enhanced US, CT and MRI
Manuscript Source	Invited Manuscript
All Author List	Yasunori Minami, Naoshi Nishida and Masatoshi Kudo
Funding Agency and Grant Number
Corresponding Author	Masatoshi Kudo, MD, PhD, Department of Gastroenterology and Hepatology, Kinki University Faculty of Medicine, 377-2 Ohno-Higashi Osaka-Sayama, Osaka 589-8511, Japan. m-kudo@med.kindai.ac.jp
Key Words	Hepatocellular carcinoma; Micrometastasis; Microvascular invasion; Radiofrequency ablation; Safety margin
Core Tip	Radiofrequency ablation (RFA) therapy is needed to ablate wider range of region than targeted tumor, including surrounding liver tissues that involve micrometastases and microvascular invasion. The local recurrence rate tends to be lower in hepatocellular carcinoma patients with an adequate ablation margin, and thus, it is essential to assess safety margin accurately to reduce local recurrence. From this point of view, we need to focus on the achievement of a sufficient ablation margin as well the lack of tumor vascular enhancement for the assessment of successful RFA. However, inflammatory hyperemia due to RFA which often appears as peripheral rim enhancement, and non-typical imaging features of tumor recurrence sometimes lead to the inappropriate diagnosis.
Publish Date	2014-04-17 13:27
Citation	Minami Y, Nishida N, Kudo M. Therapeutic response assessment of RFA for HCC: Contrast-enhanced US, CT and MRI. World J Gastroenterol 2014; 20(15): 4160-4166
URL	http://www.wjgnet.com/1007-9327/full/v20/i15/4160.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i15.4160

Full Article (PDF)	WJG-20-4160.pdf
Full Article (Word)	WJG-20-4160.doc
Manuscript File	6314-Review.doc
Answering Reviewers	6314-Answering reviewers.pdf
Copyright License Agreement	6314-Copyright assignment.pdf
Peer-review Report	6314-Peer review(s).pdf
Scientific Editor Work List	6314-Scientific editor work list.doc