Publication Name	World Journal of Gastroenterology
Manuscript ID	63224
Country	Australia

Received	2021-01-26 11:03
Peer-Review Started	2021-01-26 11:15
To Make the First Decision
Return for Revision	2021-02-27 17:42
Revised	2021-03-24 10:43
Second Decision	2021-06-15 12:50
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2021-06-15 13:20
Articles in Press	2021-06-15 13:20
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-07-07 01:37
Publish the Manuscript Online	2021-07-12 00:42

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Biomarkers in the diagnosis of pancreatic cancer: Are we closer to finding the golden ticket?
Manuscript Source	Invited Manuscript
All Author List	Robert S O'Neill and Alina Stoita
ORCID	Author(s) ORCID Number Robert S O'Neill http://orcid.org/0000-0002-9576-2248 Alina Stoita http://orcid.org/0000-0001-9460-2149
Funding Agency and Grant Number
Corresponding Author	Alina Stoita, FRACP, MBBS, Doctor, Doctor, Lecturer, Department of Gastroenterology, St Vincent's Hospital Sydney, 390 Victoria Street, Sydney 2010, Australia. alina.stoita@svha.org.au
Key Words	Pancreatic cancer; Cancer; Biomarkers; Diagnostic; Review
Core Tip	Circulating biomarkers are an attractive method for pancreatic cancer (PC) diagnosis. Over 300 biomarkers are presented in this review, however no gold standard biomarker exists. While carbohydrate antigen 19-9 possesses modest sensitivity in PC diagnosis, a lack of specificity is a limitation for its use. More recent studies have shifted towards the concept of a liquid biopsy along with measuring expression of RNA based markers in different mediums. Panels comprising multiple candidate biomarkers have emerged, demonstrating modest diagnostic value. Further studies are required to validate these findings, along with assessment in an asymptomatic population to determine their value in screening.
Publish Date	2021-07-12 00:42
Citation	O'Neill RS, Stoita A. Biomarkers in the diagnosis of pancreatic cancer: Are we closer to finding the golden ticket? World J Gastroenterol 2021; 27(26): 4045-4087
URL	https://www.wjgnet.com/1007-9327/full/v27/i26/4045.htm
DOI	https://dx.doi.org/10.3748/wjg.v27.i26.4045

Full Article (PDF)	WJG-27-4045.pdf
Full Article (Word)	WJG-27-4045.docx
Manuscript File	63224_Auto_Edited-ZMG.docx
Answering Reviewers	63224-Answering reviewers.pdf
Audio Core Tip	63224-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	63224-Conflict-of-interest statement.pdf
Copyright License Agreement	63224-Copyright license agreement.pdf
Peer-review Report	63224-Peer-review(s).pdf
Scientific Misconduct Check	63224-Bing-Wang JL-1.jpg
Scientific Misconduct Check	63224-Scientific misconduct check.pdf
Scientific Editor Work List	63224-Scientific editor work list.pdf
CrossCheck Report	63224-CrossCheck report.pdf