Publication Name	World Journal of Gastroenterology
Manuscript ID	63313
Country	China

Received	2021-01-27 13:10
Peer-Review Started	2021-01-27 13:18
To Make the First Decision
Return for Revision	2021-02-25 05:07
Revised	2021-03-12 02:37
Second Decision	2021-04-22 12:55
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-04-22 13:48
Articles in Press	2021-04-22 13:48
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-08-25 23:19
Typeset the Manuscript	2021-09-18 07:33
Publish the Manuscript Online	2021-09-23 07:48

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Scientific Journal
Manuscript Type	Review
Article Title	Histone methylation in pancreatic cancer and its clinical implications
Manuscript Source	Invited Manuscript
All Author List	Xing-Yu Liu, Chuan-Hao Guo, Zhi-Yuan Xi, Xin-Qi Xu, Qing-Yang Zhao, Li-Sha Li and Ying Wang
ORCID	Author(s) ORCID Number Xing-Yu Liu http://orcid.org/0000-0001-5800-2787 Chuan-Hao Guo http://orcid.org/0000-0001-5801-0453 Zhi-Yuan Xi http://orcid.org/0000-0002-3747-3042 Xin-Qi Xu http://orcid.org/0000-0002-7688-7619 Qing-Yang Zhao http://orcid.org/0000-0002-0386-5507 Li-Sha Li http://orcid.org/0000-0003-4048-5981 Ying Wang http://orcid.org/0000-0003-1633-0007
Funding Agency and Grant Number
Corresponding Author	Ying Wang, MM, N/A, The First Hospital of Jilin University, Jilin University, No. 126 Xinmin Street, Changchun 130021, Jilin Province, China. wangying_jy@jlu.edu.cn
Key Words	Pancreatic cancer; Epigenetics; Histone modification; Methylation; Demethylation; Clinical application
Core Tip	Pancreatic cancer is a highly lethal malignancy of the digestive tract that is difficult to diagnose and treat. Histone methylation/demethylation equilibrium is altered in carcinogenesis, resulting in changes in chromatin structure and gene expression. Not only histone methylation writer and eraser are related to each other, but there are also relationships between histone methylation modification and other epigenetic modifications. Therefore, histone methylation is addressed as a potentially important chemotherapy drug target.
Publish Date	2021-09-23 07:48
Citation	Liu XY, Guo CH, Xi ZY, Xu XQ, Zhao QY, Li LS, Wang Y. Histone methylation in pancreatic cancer and its clinical implications. World J Gastroenterol 2021; 27(36): 6004-6024
URL	https://www.wjgnet.com/1007-9327/full/v27/i36/6004.htm
DOI	https://dx.doi.org/10.3748/wjg.v27.i36.6004

Full Article (PDF)	WJG-27-6004.pdf
Full Article (Word)	WJG-27-6004.docx
Manuscript File	63313-Review-FilipodiaCL.docx
Answering Reviewers	63313-Answering reviewers.pdf
Audio Core Tip	63313-Audio core tip.aac
Conflict-of-Interest Disclosure Form	63313-Conflict-of-interest statement.pdf
Copyright License Agreement	63313-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	63313-Language certificate.pdf
Peer-review Report	63313-Peer-review(s).pdf
Scientific Misconduct Check	63313-Scientific misconduct check.pdf
Scientific Editor Work List	63313-Scientific editor work list.pdf