Publication Name	World Journal of Gastroenterology
Manuscript ID	63329
Country	Italy

Received	2021-01-27 12:38
Peer-Review Started	2021-01-27 12:47
To Make the First Decision
Return for Revision	2021-02-24 06:29
Revised	2021-03-05 08:59
Second Decision	2021-04-02 12:32
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2021-04-05 18:28
Articles in Press	2021-04-05 18:28
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-04-12 20:32
Typeset the Manuscript	2021-04-27 01:38
Publish the Manuscript Online	2021-04-29 02:12

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Mesenchymal stromal cells secretome in liver failure: Perspectives on COVID-19 infection treatment
Manuscript Source	Invited Manuscript
All Author List	Cinzia Maria Chinnici, Giovanna Russelli, Matteo Bulati, Vitale Miceli, Alessia Gallo, Rosalia Busà, Rosaria Tinnirello, Pier Giulio Conaldi and Gioacchin Iannolo
ORCID	Author(s) ORCID Number Cinzia Maria Chinnici http://orcid.org/0000-0001-9318-6606 Giovanna Russelli http://orcid.org/0000-0002-1920-0892 Matteo Bulati http://orcid.org/0000-0002-3269-935X Vitale Miceli http://orcid.org/0000-0001-8922-9909 Alessia Gallo http://orcid.org/0000-0001-6737-9770 Rosalia Busà http://orcid.org/0000-0002-7546-7209 Rosaria Tinnirello http://orcid.org/0000-0002-4324-5097 Pier Giulio Conaldi http://orcid.org/0000-0003-1994-8005 Gioacchin Iannolo http://orcid.org/0000-0002-7710-4735
Funding Agency and Grant Number	Funding Agency Grant Number UPMC International, Pittsburg, United States I0000026 Italian Ministry of Education, University and Research, Rome, Italy CTN01_00177_888744 PO FESR Sicilia 2014/2020 Azione 1.1.5 Project (Prometeo) 08PA8610200270
Corresponding Author	Gioacchin Iannolo, PhD, Research Scientist, Department of Research, Mediterranean Institute for Transplantation and Advanced Specialized Therapies (IRCCS-ISMETT), Via Ernesto Tricomi, 5, Palermo 90127, Palermo, Italy. giannolo@ismett.edu
Key Words	Mesenchymal stromal cell; COVID-19; SARS-CoV-2; Organ failure; Inflammation; Transplantation
Core Tip	The recent coronavirus disease 2019 (COVID-19) pandemic outbreak due to the newly identified coronavirus, severe acute respiratory syndrome coronavirus 2, has forced scientists worldwide to use all the available options to fight this disease, in particular the inflammatory cascade caused by this infection. Mesenchymal stromal cells, for their immunomodulatory potential, represents a valid approach to combat organ inflammation. The main targets for this virus are the lungs, while other organs, such as the liver, are compromised by the infection. The evaluation of the albumin role in COVID-19 patients, and the connection to the “capillary leak syndrome” have focused attention on liver dysfunction correlated with the infection.
Publish Date	2021-04-29 02:12
Citation	Chinnici CM, Russelli G, Bulati M, Miceli V, Gallo A, Busà R, Tinnirello R, Conaldi PG, Iannolo G. Mesenchymal stromal cells secretome in liver failure: Perspectives on COVID-19 infection treatment. World J Gastroenterol 2021; 27(17): 1905-1919
URL	https://www.wjgnet.com/1007-9327/full/v27/i17/1905.htm
DOI	https://dx.doi.org/10.3748/wjg.v27.i17.1905

Full Article (PDF)	WJG-27-1905.pdf
Full Article (Word)	WJG-27-1905.docx
Manuscript File	63329-Review-FilipodiaCL.docx
Answering Reviewers	63329-Answering reviewers.pdf
Audio Core Tip	63329-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	63329-Conflict-of-interest statement.pdf
Copyright License Agreement	63329-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	63329-Grant application form(s).PDF
Non-Native Speakers of English Editing Certificate	63329-Language certificate.pdf
Peer-review Report	63329-Peer-review(s).pdf
Scientific Misconduct Check	63329-Scientific misconduct check.pdf
Scientific Editor Work List	63329-Scientific editor work list.pdf
CrossCheck Report	63329-CrossCheck report.pdf