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Articles Published Processes
7/26/2021 11:20:59 AM | Browse: 843 | Download: 1738
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Received |
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2021-01-28 18:47 |
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Peer-Review Started |
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2021-01-28 19:09 |
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First Decision by Editorial Office Director |
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2021-05-02 00:55 |
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Return for Revision |
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2021-05-02 00:55 |
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Revised |
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2021-05-28 17:41 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2021-06-22 13:33 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2021-06-22 14:27 |
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Articles in Press |
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2021-06-22 14:27 |
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Edit the Manuscript by Language Editor |
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2021-06-28 22:42 |
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Typeset the Manuscript |
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2021-07-19 02:35 |
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Publish the Manuscript Online |
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2021-07-26 11:20 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Review |
| Article Title |
Modulation of cell physiology under hypoxia in pancreatic cancer
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Matias Estaras and Antonio Gonzalez |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Ministerio de Economía y Competitividad |
BFU2016-79259-R |
| Junta de Extremadura-FEDER |
GR18070 |
| Valhondo Calaff Foundation |
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| Corresponding Author |
Antonio Gonzalez, DVM, Full Professor, Department of Physiology, Cell Biology and Communication Research Group, University of Extremadura, Ave Ciencias s/n, Caceres 10003, Spain. agmateos@unex.es |
| Key Words |
Hypoxia; Cancer; Tumor; Pancreas; Proliferation; Cell survival |
| Core Tip |
Pancreatic ductal adenocarcinoma is characterized by high aggressiveness, therapeutic resistance, and mortality. The cells included in the mass, both tumor and those forming the stroma, exhibit a high proliferative rate that leads to the rapid growth of the tumor. Because of this, the distribution of blood vessels is insufficient for oxygen supply to the cells. As a consequence, a condition of hypoxia is set. Cells escape from death by terms of adaptation and undergo critical changes in intracellular pathways directed to energy supply, proliferation and cell-to-cell communication. |
| Publish Date |
2021-07-26 11:20 |
| Citation |
Estaras M, Gonzalez A. Modulation of cell physiology under hypoxia in pancreatic cancer. World J Gastroenterol 2021; 27(28): 4582-4602 |
| URL |
https://www.wjgnet.com/1007-9327/full/v27/i28/4582.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v27.i28.4582 |
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