Publication Name	World Journal of Gastroenterology
Manuscript ID	63433
Country	Spain

Received	2021-01-28 18:47
Peer-Review Started	2021-01-28 19:09
To Make the First Decision
Return for Revision	2021-05-02 00:55
Revised	2021-05-28 17:41
Second Decision	2021-06-22 13:33
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2021-06-22 14:27
Articles in Press	2021-06-22 14:27
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-06-28 22:42
Typeset the Manuscript	2021-07-19 02:35
Publish the Manuscript Online	2021-07-26 11:20

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Cell Biology
Manuscript Type	Review
Article Title	Modulation of cell physiology under hypoxia in pancreatic cancer
Manuscript Source	Invited Manuscript
All Author List	Matias Estaras and Antonio Gonzalez
ORCID	Author(s) ORCID Number Matias Estaras http://orcid.org/0000-0003-3462-7904 Antonio Gonzalez http://orcid.org/0000-0001-8380-0270
Funding Agency and Grant Number	Funding Agency Grant Number Ministerio de Economía y Competitividad BFU2016-79259-R Junta de Extremadura-FEDER GR18070 Valhondo Calaff Foundation
Corresponding Author	Antonio Gonzalez, DVM, Full Professor, Department of Physiology, Cell Biology and Communication Research Group, University of Extremadura, Ave Ciencias s/n, Caceres 10003, Spain. agmateos@unex.es
Key Words	Hypoxia; Cancer; Tumor; Pancreas; Proliferation; Cell survival
Core Tip	Pancreatic ductal adenocarcinoma is characterized by high aggressiveness, therapeutic resistance, and mortality. The cells included in the mass, both tumor and those forming the stroma, exhibit a high proliferative rate that leads to the rapid growth of the tumor. Because of this, the distribution of blood vessels is insufficient for oxygen supply to the cells. As a consequence, a condition of hypoxia is set. Cells escape from death by terms of adaptation and undergo critical changes in intracellular pathways directed to energy supply, proliferation and cell-to-cell communication.
Publish Date	2021-07-26 11:20
Citation	Estaras M, Gonzalez A. Modulation of cell physiology under hypoxia in pancreatic cancer. World J Gastroenterol 2021; 27(28): 4582-4602
URL	https://www.wjgnet.com/1007-9327/full/v27/i28/4582.htm
DOI	https://dx.doi.org/10.3748/wjg.v27.i28.4582

Full Article (PDF)	WJG-27-4582.pdf
Full Article (Word)	WJG-27-4582.docx
Manuscript File	63433_Review-FilipodiaCL.docx
Answering Reviewers	63433-Answering reviewers.pdf
Audio Core Tip	63433-Audio core tip.wav
Conflict-of-Interest Disclosure Form	63433-Conflict-of-interest statement.pdf
Copyright License Agreement	63433-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	63433-Grant application form(s).pdf
Peer-review Report	63433-Peer-review(s).pdf
Scientific Misconduct Check	63433-Scientific misconduct check.pdf
Scientific Editor Work List	63433-Scientific editor work list.pdf
CrossCheck Report	63433-CrossCheck report.pdf