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Articles Published Processes
10/13/2021 8:37:10 AM | Browse: 291 | Download: 513
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Received |
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2021-01-28 10:37 |
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Peer-Review Started |
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2021-01-28 10:40 |
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To Make the First Decision |
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Return for Revision |
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2021-05-03 21:55 |
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Revised |
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2021-05-22 07:21 |
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Second Decision |
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2021-07-05 05:47 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-07-05 09:35 |
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Articles in Press |
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2021-07-05 09:35 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2021-09-04 05:19 |
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Typeset the Manuscript |
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2021-09-30 12:11 |
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Publish the Manuscript Online |
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2021-10-13 08:37 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Immunology |
| Manuscript Type |
Review |
| Article Title |
Role of nucleic acid sensing in the pathogenesis of type-1 diabetes
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Darshan Badal, Naresh Sachdeva, Deep Maheshwari and Preetam Basak |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Council of Scientific and Industrial Research, Government of India |
27 (0328)/17/EMR-II (awarded to Sachdeva N) |
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| Corresponding Author |
Naresh Sachdeva, MSc, PhD, Additional Professor, Department of Endocrinology, Post Graduate Institute of Medical Education and Research, Sector 12, Chandigarh 160012, India. naresh_pgi@hotmail.com |
| Key Words |
Nucleic acid sensing; Type-1 diabetes; Pattern recognition receptors; Nucleic acid receptors; Type-1 interferon; Beta cells |
| Core Tip |
Under abnormal physiological conditions such as excessive cellular stress or apoptosis, endogenous self-nucleic acids like DNA, RNA or mitochondrial DNA accumulate in extranuclear compartments or extracellular spaces or form complexes with host proteins. Such situations sometimes lead to the failure of discriminating mechanisms of nucleic acid sensors leading to proinflammatory responses as seen in autoimmune diseases like systemic lupus erythematosus, psoriasis and to some extent in type-1 diabetes (T1D). The understanding of the role of nucleic acid-sensing and their downstream signaling pathways is gradually evolving and provides another avenue in exploring therapeutic options for treating autoimmune diseases like T1D. |
| Publish Date |
2021-10-13 08:37 |
| Citation |
Badal D, Sachdeva N, Maheshwari D, Basak P. Role of nucleic acid sensing in the pathogenesis of type-1 diabetes. World J Diabetes 2021; 12(10): 1654-1673 |
| URL |
https://www.wjgnet.com/1948-9358/full/v12/i10/1655.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v12.i10.1655 |
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