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Articles Published Processes
8/10/2021 6:48:42 AM | Browse: 627 | Download: 1097
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Received |
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2021-01-28 15:06 |
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Peer-Review Started |
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2021-01-28 15:14 |
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To Make the First Decision |
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Return for Revision |
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2021-05-02 02:06 |
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Revised |
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2021-05-17 08:53 |
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Second Decision |
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2021-07-20 03:28 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-07-20 09:14 |
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Articles in Press |
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2021-07-20 09:14 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2021-08-06 10:29 |
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Publish the Manuscript Online |
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2021-08-10 06:48 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Review |
| Article Title |
Stress-activated kinases as therapeutic targets in pancreatic cancer
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Benno Traub, Aileen Roth, Marko Kornmann, Uwe Knippschild and Joachim Bischof |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| German Research Foundation (DFG) |
TR1663/1-1 |
| German Research Foundation (DFG) |
KN356/9-1 |
| Else Kröner-Fresenius-Stiftung |
2017_A142 |
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| Corresponding Author |
Uwe Knippschild, PhD, Professor, Department of General and Visceral Surgery, Ulm University Hospital, Albert-Einstein-Allee 23, Ulm 89081, Germany. uwe.knippschild@uniklinik-ulm.de |
| Key Words |
Pancreatic cancer; Stress-activated protein kinases; Mitogen-activated protein kinases; c-Jun N-terminal kinases; Casein kinase 1; Small molecule inhibitor |
| Core Tip |
Since pancreatic cancer patients are generally confronted with poor prognosis, optimized therapeutic strategies are urgently needed. To establish new treatment options, efforts in drug development have increasingly focused on targeting protein kinases. In the cellular response to various stress signals, c-Jun N-terminal kinases (JNK) and p38 kinases as well as members of the casein kinase 1 (CK1) family are of special interest. Concentrating on pancreatic carcinoma in this review, we summarize the key roles of JNK, p38, and CK1 and provide an overview of recent achievements in the development of small molecule kinase inhibitors against these kinases. |
| Publish Date |
2021-08-10 06:48 |
| Citation |
Traub B, Roth A, Kornmann M, Knippschild U, Bischof J. Stress-activated kinases as therapeutic targets in pancreatic cancer. World J Gastroenterol 2021; 27(30): 4963-4984 |
| URL |
https://www.wjgnet.com/1007-9327/full/v27/i30/4963.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v27.i30.4963 |
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