Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	63592
Country	United States

Received	2021-01-29 21:50
Peer-Review Started	2021-01-29 21:56
To Make the First Decision
Return for Revision	2021-04-06 05:39
Revised	2021-04-13 22:14
Second Decision	2021-05-10 09:33
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-05-10 09:49
Articles in Press	2021-05-10 09:49
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-06-03 00:36
Publish the Manuscript Online	2021-06-07 11:17

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Minireviews
Article Title	Targeting of elevated cell surface phosphatidylserine with saposin C-dioleoylphosphatidylserine nanodrug as individual or combination therapy for pancreatic cancer
Manuscript Source	Invited Manuscript
All Author List	Harold W Davis, Ahmet Kaynak, Subrahmanya D Vallabhapurapu and Xiaoyang Qi
ORCID	Author(s) ORCID Number Harold W Davis http://orcid.org/0000-0001-9308-8264H Ahmet Kaynak http://orcid.org/0000-0001-6551-1125 Subrahmanya D Vallabhapurapu http://orcid.org/0000-0002-7924-0175 Xiaoyang Qi http://orcid.org/0000-0001-5363-1760
Funding Agency and Grant Number	Funding Agency Grant Number Pancreatic Cancer Action Network Translational Research Grant 20-65-QIXI Give Hope Foundation, National Institutes of Health R01CA158372 Give Hope Foundation, National Institutes of Health R21NS095047 CCTST Pilot Collaborative Studies, Bearcats Against Cancer, and Hematology-Oncology Programmatic Support from University of Cincinnati College of Medicine
Corresponding Author	Xiaoyang Qi, PhD, Professor, Division of Hematology/Oncology, Department of Internal Medicine, University of Cincinnati College of Medicine, Brain Tumor Center at UC Neuroscience Institute, 3512 Eden Avenue, Cincinnati, OH 45267, United States. xiaoyang.qi@uc.edu
Key Words	Pancreatic cancer; Saposin C; Dioleoylphosphatidylserine; Phosphatidylserine-targeted therapy; Chemotherapy; Radiation
Core Tip	This review presents the mechanisms and efficacy of saposin C-dioleoylphosphatidylserine (SapC-DOPS), a novel phosphatidylserine (PS) biomarker-targeted nanodrug, alone and in combination with other treatment modalities for the treatment of pancreatic ductal adenocarcinoma (PDAC) tumors. Our results indicate that SapC-DOPS preferentially targets cells with high surface PS which are primarily in the G2/M phase of the cell cycle. Other treatment modalities such as Gemcitabine, Abraxane and radiation target G1 phase cells that have low surface PS. Combination of SapC-DOPS and Gemcitabine/Abraxane or radiation significantly inhibits tumor growth of orthotopic PDAC tumors in vivo and increases survival compared to individual treatments.
Publish Date	2021-06-07 11:17
Citation	Davis HW, Kaynak A, Vallabhapurapu SD, Qi X. Targeting of elevated cell surface phosphatidylserine with saposin C-dioleoylphosphatidylserine nanodrug as individual or combination therapy for pancreatic cancer. World J Gastrointest Oncol 2021; 13(6): 550-559
URL	https://www.wjgnet.com/1948-5204/full/v13/i6/550.htm
DOI	https://dx.doi.org/10.4251/wjgo.v13.i6.550

Full Article (PDF)	WJGO-13-550.pdf
Full Article (Word)	WJGO-13-550.docx
Manuscript File	63592_Auto_Edited-ZMG.docx
Answering Reviewers	63592-Answering reviewers.pdf
Audio Core Tip	63592-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	63592-Conflict-of-interest statement.pdf
Copyright License Agreement	63592-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	63592-Grant application form(s).pdf
Peer-review Report	63592-Peer-review(s).pdf
Scientific Misconduct Check	63592-Bing-Yan JP-1.jpg
Scientific Misconduct Check	63592-Scientific misconduct check.pdf
Scientific Editor Work List	63592-Scientific editor work list.pdf