Publication Name	World Journal of Stem Cells
Manuscript ID	63664
Country	China

Received	2021-02-01 03:50
Peer-Review Started	2021-02-01 03:55
To Make the First Decision
Return for Revision	2021-02-28 05:28
Revised	2021-03-11 14:55
Second Decision	2021-03-29 07:54
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2021-03-29 20:11
Articles in Press	2021-03-29 20:11
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-04-07 03:50
Typeset the Manuscript	2021-04-21 05:58
Publish the Manuscript Online	2021-04-22 10:31

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Cell Biology
Manuscript Type	Basic Study
Article Title	Hypoxia-inducible factor-1α–mediated upregulation of CD99 promotes the proliferation of placental mesenchymal stem cells by regulating ERK1/2
Manuscript Source	Unsolicited Manuscript
All Author List	Xu-Dong Feng, Jia-Qi Zhu, Jia-Hang Zhou, Fei-Yan Lin, Bing Feng, Xiao-Wei Shi, Qiao-Ling Pan, Jiong Yu, Lan-Juan Li and Hong-Cui Cao
ORCID	Author(s) ORCID Number Xu-Dong Feng http://orcid.org/0000-0002-4103-7737 Jia-Qi Zhu http://orcid.org/0000-0001-9472-4074 Jia-Hang Zhou http://orcid.org/0000-0003-0623-517X Fei-Yan Lin http://orcid.org/0000-0002-9064-1033 Bing Feng http://orcid.org/0000-0002-2385-0417 Xiao-Wei Shi http://orcid.org/0000-0002-0461-9076 Qiao-Ling Pan http://orcid.org/0000-0002-3771-8193 Jiong Yu http://orcid.org/0000-0002-1821-1178 Lan-Juan Li http://orcid.org/0000-0001-6945-0593 Hong-Cui Cao http://orcid.org/0000-0002-6604-6867
Funding Agency and Grant Number	Funding Agency Grant Number Stem Cell and Translational Research from National Key Research and Development Program of China 2020YFA0113003 National Natural Science Foundation of China 81971756
Corresponding Author	Hong-Cui Cao, MD, PhD, Professor, State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, No. 79 Qingchun Road, Hangzhou 310003, Zhejiang Province, China. hccao@zju.edu.cn
Key Words	Hypoxia-inducible factor 1α; Hypoxia; Mesenchymal stem cells; Proliferation; CD99; RNA-sequencing assay; MAPK/ERK signaling pathway
Core Tip	This study demonstrated that the potential of hypoxic condition on human placenta-derived mesenchymal stem cells (hP-MSCs) to enhance the proliferation capacity. Through the use of RNA sequencing assays and molecular biology experiments, a novel gene CD99 was found to be involved in hypoxia-mediated promotion of hP-MSCs proliferation. Furthermore, it indicated that CD99 activates pathways that transport ERK1/2 to the nucleus, increasing the activity of cell cycle-associated proteins. Accordingly, hypoxia-inducible factor 1α-mediated CD99 plays a role in proliferation by regulating the MAPK/ERK signaling pathway.
Publish Date	2021-04-22 10:31
Citation	Feng XD, Zhu JQ, Zhou JH, Lin FY, Feng B, Shi XW, Pan QL, Yu J, Li LJ, Cao HC. Hypoxia-inducible factor-1α–mediated upregulation of CD99 promotes the proliferation of placental mesenchymal stem cells by regulating ERK1/2. World J Stem Cells 2021; 13(4): 317-330
URL	https://www.wjgnet.com/1948-0210/full/v13/i4/317.htm
DOI	https://dx.doi.org/10.4252/wjsc.v13.i4.317

Full Article (PDF)	WJSC-13-317.pdf
Full Article (Word)	WJSC-13-317.docx
Manuscript File	63664-Review-FilipodiaCL.docx
Answering Reviewers	63664-Answering reviewers.pdf
Audio Core Tip	63664-Audio core tip.mp3
Biostatistics Review Certificate	63664-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	63664-Conflict-of-interest statement.pdf
Copyright License Agreement	63664-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	63664-Grant application form(s).pdf
Institutional Review Board Approval Form or Document	63664-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	63664-Language certificate.pdf
Supplementary Material	63664-Supplementary material.pdf
Peer-review Report	63664-Peer-review(s).pdf
Scientific Misconduct Check	63664-Scientific misconduct check.pdf
Scientific Editor Work List	63664-Scientific editor work list.pdf
CrossCheck Report	63664-CrossCheck report.pdf