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Articles Published Processes
7/21/2021 8:24:10 AM | Browse: 329 | Download: 957
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Received |
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2021-02-03 08:57 |
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Peer-Review Started |
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2021-02-03 09:02 |
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To Make the First Decision |
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Return for Revision |
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2021-03-15 00:56 |
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Revised |
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2021-03-22 09:01 |
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Second Decision |
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2021-05-26 10:17 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-05-26 13:02 |
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Articles in Press |
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2021-05-26 13:02 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2021-06-06 10:11 |
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Typeset the Manuscript |
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2021-07-02 09:24 |
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Publish the Manuscript Online |
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2021-07-21 08:24 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Observational Study |
| Article Title |
Potential protein–phenotype correlation in 3 LPS-responsive beige-like anchor protein-deficient patients
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Wen-Juan Tang, Wen-Hui Hu, Ying Huang, Bing-Bing Wu, Xiao-Min Peng, Xiao-Wen Zhai, Xiao-Wen Qian, Zi-Qing Ye, Hai-Jiao Xia, Jie Wu and Jie-Ru Shi |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Ying Huang, MD, PhD, Chief Doctor, Professor, Department of Gastroenterology, Pediatric Inflammatory Bowel Disease Research Center, Children’s Hospital of Fudan University, National Children's Medical Center, Wanyuan Road 399, Shanghai 201102, China. yhuang2019@126.com |
| Key Words |
LPS-responsive beige-like anchor protein deficiency; Chinese; Common variable immunodeficiency; Gene mutation; Chronic diarrhea |
| Core Tip |
Previous studies showed that there is no apparent genotype–phenotype correlation for LPS-responsive beige-like anchor protein (LRBA) deficiency, but may have protein–phenotype correlation. In this study we described 3 Chinese patients with LRBA deficiency, though all their major clinical findings indicated enteropathy, but they have different endoscopy findings and different response to the immunosuppressive treatment. Functional experiments revealed that a lack of LRBA protein expression may lead to worse disease outcomes and be an indicator for hematopoietic stem cell transplantation (HSCT). The results of this study will be valuable for the selection of an immunosuppressive treatment or HSCT for treating LRBA-deficient patients in the future. |
| Publish Date |
2021-07-21 08:24 |
| Citation |
Tang WJ, Hu WH, Huang Y, Wu BB, Peng XM, Zhai XW, Qian XW, Ye ZQ, Xia HJ, Wu J, Shi JR. Potential protein–phenotype correlation in 3 LPS-responsive beige-like anchor protein-deficient patients. World J Clin Cases 2021; 9(21): 5873-5888 |
| URL |
https://www.wjgnet.com/2307-8960/full/v9/i21/5873.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v9.i21.5873 |
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