Publication Name	World Journal of Gastroenterology
Manuscript ID	6383
Country	Ireland

Received	2013-10-15 15:54
Peer-Review Started	2013-10-16 14:52
First Decision by Editorial Office Director
Return for Revision	2013-12-26 18:06
Revised
Publication Fee Transferred
Second Decision by Editor	2014-02-27 11:17
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2014-02-27 11:32
Articles in Press
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-03-26 18:37
Publish the Manuscript Online	2014-04-14 10:49

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Gastro-intestinal toxicity of chemotherapeutics in colorectal cancer: The role of inflammation
Manuscript Source	Invited Manuscript
All Author List	Chun Seng Lee, Elizabeth J Ryan and Glen A Doherty
Funding Agency and Grant Number	Funding Agency Grant Number University College Dublin Foundation Helsinn-Birex Pharmaceuticals
Corresponding Author	Dr. Glen A Doherty, Centre for Colorectal Disease, St. Vincent’s University Hospital, Elm Park, Dublin 4, Ireland. glen.doherty@ucd.ie
Key Words	Chemotherapy; Diarrhea; Side-effects; Immunogenic cell death; Pro-inflammatory cytokines
Core Tip	Many new drugs are available for use in the treatment of colorectal cancer, resulting in improved prognosis, but also more frequent and severe side-effects. In order to implement complex chemotherapy regimens most effectively, a greater understanding of the underlying mechanisms of associated toxicities are required. Different chemotherapeutic agents activate a diverse range of pro-inflammatory pathways culminating in distinct histopathological changes in intestinal mucosa. However, inflammation also has beneficial effects; enhancing anti-tumor immunity. A better understanding of how to manage the gastrointestinal side-effects of chemotherapy allowing for optimal dosing and induction of immunity will further improve outcomes in colorectal cancer.
Publish Date	2014-04-14 10:49
Citation	Lee CS, Ryan EJ, Doherty GA. Gastro-intestinal toxicity of chemotherapeutics in colorectal cancer: The role of inflammation. World J Gastroenterol 2014; 20(14): 3751-3761
URL	http://www.wjgnet.com/1007-9327/full/v20/i14/3751.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i14.3751

Full Article (PDF)	WJG-20-3751.pdf
Full Article (Word)	WJG-20-3751.doc
Manuscript File	6383-Review.docx
Answering Reviewers	6383-Answering reviewers.pdf
Copyright License Agreement	6383-Copyright assignment.pdf
Peer-review Report	6383-Peer review(s).pdf
Scientific Editor Work List	6383-Scientific editor work list.doc