Publication Name	World Journal of Clinical Oncology
Manuscript ID	63860
Country	China

Received	2021-02-05 03:56
Peer-Review Started	2021-02-05 04:01
To Make the First Decision
Return for Revision	2021-03-31 04:56
Revised	2021-04-13 04:25
Second Decision	2021-06-02 10:48
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2021-06-02 12:56
Articles in Press	2021-06-02 12:56
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-06-09 23:40
Typeset the Manuscript	2021-07-19 02:59
Publish the Manuscript Online	2021-07-21 09:30

ISSN	2218-4333 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Proteoglycans and their functions in esophageal squamous cell carcinoma
Manuscript Source	Invited Manuscript
All Author List	Yun Zhu and Annie Lai Man Cheung
ORCID	Author(s) ORCID Number Yun Zhu http://orcid.org/0000-0001-6656-3891 Annie Lai Man Cheung http://orcid.org/0000-0003-3217-1456
Funding Agency and Grant Number	Funding Agency Grant Number Research Grants Council of the Hong Kong SAR, China 17111016 Research Grants Council of the Hong Kong SAR, China 17100819
Corresponding Author	Annie Lai Man Cheung, BSc, PhD, Associate Professor, School of Biomedical Sciences, The University of Hong Kong, Laboratory Block, No. 21 Sassoon Road, Hong Kong 999077, China. lmcheung@hku.hk
Key Words	Esophageal squamous cell carcinoma; Proteoglycan; Glycosaminoglycan; Serglycin; Extracellular matrix; Biomarker
Core Tip	Esophageal squamous cell carcinoma (ESCC) is a highly malignant human cancer because of its early metastasis and late diagnosis. Cancer metastasis involves multiple steps that involve cell-cell and cell-matrix interactions in the tumor microenvironment. Proteoglycans are one of the components of the extracellular matrix that play an important role in cell-matrix interactions. We herein summarizes the proteoglycans that have been studied in ESCC to provide a comprehensive view of the role of proteoglycans in ESCC.
Publish Date	2021-07-21 09:30
Citation	Zhu Y, Cheung ALM. Proteoglycans and their functions in esophageal squamous cell carcinoma. World J Clin Oncol 2021; 12(7): 507-521
URL	https://www.wjgnet.com/2218-4333/full/v12/i7/507.htm
DOI	https://dx.doi.org/10.5306/wjco.v12.i7.507

Full Article (PDF)	WJCO-12-507.pdf
Full Article (Word)	WJCO-12-507.docx
Manuscript File	63860-Review-Filipodia-CL.docx
Answering Reviewers	63860-Answering reviewers.pdf
Audio Core Tip	63860-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	63860-Conflict-of-interest statement.pdf
Copyright License Agreement	63860-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	63860-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	63860-Language certificate.pdf
Peer-review Report	63860-Peer-review(s).pdf
Scientific Misconduct Check	63860-Bing-Wang JL-1.jpg
Scientific Misconduct Check	63860-Scientific misconduct check.pdf
Scientific Editor Work List	63860-Scientific editor work list.pdf
CrossCheck Report	63860-CrossCheck report.pdf