Publication Name	World Journal of Psychiatry
Manuscript ID	63863
Country	Germany

Received	2021-02-04 10:30
Peer-Review Started	2021-02-04 10:37
To Make the First Decision
Return for Revision	2021-04-21 00:18
Revised	2021-04-30 08:54
Second Decision	2021-11-22 03:35
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2021-11-25 02:47
Articles in Press	2021-11-25 02:47
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-11-17 04:04
Typeset the Manuscript	2021-11-29 08:38
Publish the Manuscript Online	2021-12-15 09:38

ISSN	2220-3206 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Neurosciences
Manuscript Type	Review
Article Title	Polyamines and polyamine-metabolizing enzymes in schizophrenia: Current knowledge and concepts of therapy
Manuscript Source	Invited Manuscript
All Author List	Hans-Gert Bernstein, Gerburg Keilhoff, Gregor Laube, Henrik Dobrowolny and Johann Steiner
ORCID	Author(s) ORCID Number Hans-Gert Bernstein http://orcid.org/0000-0002-2594-1689 Gerburg Keilhoff http://orcid.org/0000-0001-8836-2679 Gregor Laube http://orcid.org/0000-0002-4102-3301 Henrik Dobrowolny http://orcid.org/0000-0003-3393-3037 Johann Steiner http://orcid.org/0000-0002-2611-2268
Funding Agency and Grant Number
Corresponding Author	Hans-Gert Bernstein, PhD, Emeritus Professor, Department of Psychiatry, University of Magdeburg, Leipziger Str. 44, Magdeburg D-39116, Saxony-Anhalt, Germany. hans-gert.bernstein@med.ovgu.de
Key Words	Polyamines; Spermidine; Spermine; Schizophrenia; Animal models; Therapy
Core Tip	This review summarizes the advancements in research on the implications of polyamines and their metabolites for schizophrenia. Evidence from clinical and experimental studies show that some members of the polyamine regulatory system are altered in schizophrenia, but no polyamine-based therapy for schizophrenia is currently available.
Publish Date	2021-12-15 09:38
Citation	Bernstein HG, Keilhoff G, Laube G, Dobrowolny H, Steiner J. Polyamines and polyamine-metabolizing enzymes in schizophrenia: Current knowledge and concepts of therapy. World J Psychiatr 2021; 11(12): 1177-1190
URL	https://www.wjgnet.com/2220-3206/full/v11/i12/1177.htm
DOI	https://dx.doi.org/10.5498/wjp.v11.i12.1177

Full Article (PDF)	WJP-11-1177.pdf
Full Article (Word)	WJP-11-1177.docx
Manuscript File	63863_Auto_Edited-ZMG-Filipodia.docx
Answering Reviewers	63863-Answering reviewers.pdf
Audio Core Tip	63863-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	63863-Conflict-of-interest statement.pdf
Copyright License Agreement	63863-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	63863-Language certificate.pdf
Peer-review Report	63863-Peer-review(s).pdf
Scientific Misconduct Check	63863-CrossCheck.png
Scientific Editor Work List	63863-Scientific editor work list.pdf
CrossCheck Report	63863-CrossCheck report.pdf