| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Risk factors and prognostic value of acute severe lower gastrointestinal bleeding in Crohn’s disease
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Jiyoung Yoon, Dae Sung Kim, Ye-Jee Kim, Jin Wook Lee, Seung Wook Hong, Ha Won Hwang, Sung Wook Hwang, Sang Hyoung Park, Dong-Hoon Yang, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung and Suk-Kyun Yang |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Suk-Kyun Yang, PhD, Professor, Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, South Korea. sky@amc.seoul.kr |
| Key Words |
Gastrointestinal hemorrhage; Lower gastrointestinal tract; Crohn’s disease; Risk factors; Cohort studies; Clinical course |
| Core Tip |
A retrospective cohort study was conducted to identify the predictors of acute severe lower gastrointestinal bleeding (LGIB) in Crohn’s disease (CD) and the impact of acute severe LGIB on the subsequent clinical course thereof. In multivariable analysis, early use of thiopurines and female sex were associated with a lower risk of acute severe LGIB. Moreover, matched analyses within the cohort demonstrated that the risks of behavioral progression, intestinal resection, and hospitalization due to non-bleeding causes did not significantly differ according to bleeding, which suggests that a history of acute severe LGIB may not have a significant prognostic value in CD. |
| Publish Date |
2021-05-13 10:05 |
| Citation |
Yoon J, Kim DS, Kim YJ, Lee JW, Hong SW, Hwang HW, Hwang SW, Park SH, Yang DH, Ye BD, Byeon JS, Myung SJ, Yang SK. Risk factors and prognostic value of acute severe lower gastrointestinal bleeding in Crohn’s disease. World J Gastroenterol 2021; 27(19): 2353-2365 |
| URL |
https://www.wjgnet.com/1007-9327/full/v27/i19/2353.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v27.i19.2353 |
