Publication Name	World Journal of Clinical Cases
Manuscript ID	63923
Country	China

Received	2021-02-06 04:38
Peer-Review Started	2021-02-06 04:43
To Make the First Decision
Return for Revision	2021-03-25 05:19
Revised	2021-03-27 10:34
Second Decision	2021-05-17 07:29
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-05-17 11:53
Articles in Press	2021-05-17 11:53
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-05-24 02:35
Typeset the Manuscript	2021-06-16 11:14
Publish the Manuscript Online	2021-06-24 07:26

ISSN	2307-8960 (online)
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Category	Toxicology
Manuscript Type	Observational Study
Article Title	Early diagnosis, treatment, and outcomes of five patients with acute thallium poisoning
Manuscript Source	Unsolicited Manuscript
All Author List	Ting-Ting Wang, Bing Wen, Xiu-Nan Yu, Zhang-Ge Ji, Yi-Yong Sun, Ying Li, Shou-Lian Zhu, Yong-Liang Cao, Mei Wang, Xiang-Dong Jian and Tan Wang
ORCID	Author(s) ORCID Number Ting-Ting Wang http://orcid.org/0000-0002-1514-5283 Bing Wen http://orcid.org/0000-0001-8141-6662 Xiu-Nan Yu http://orcid.org/0000-0002-4022-9147 Zhang-Ge Ji http://orcid.org/0000-0002-3030-6532 Yi-Yong Sun http://orcid.org/0000-0003-0065-4162 Ying Li http://orcid.org/0000-0003-4415-4514 Shou-Lian Zhu http://orcid.org/0000-0002-8528-2603 Yong-Liang Cao http://orcid.org/0000-0002-4580-5596 Mei Wang http://orcid.org/0000-0002-2215-5316 Xiang-Dong Jian http://orcid.org/0000-0002-2378-9935 Tan Wang http://orcid.org/0000-0002-1061-161X
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81701058 Shandong Academy of Sciences ZR2017PH027 China Postdoctoral Science Foundation 2017M612288
Corresponding Author	Tan Wang, MD, PhD, Professor, Department of Geriatrics, Qilu hospital of Shandong University, No. 107 West Wenhua Road, Jinan 250012, Shandong Province, China. olivelwang@sdu.edu.cn
Key Words	Thallium poisoning; Hyperalgesia; Abdominalgia; Hemoperfusion; Prussian blue; Outcomes
Core Tip	Thallium poisoning is rare and easily to be misdiagnosed. In this study, dysesthesia of limbs with hyperalgesia and abdominalgia were the main initial symptoms of the five patients who had a thallium-contaminating meal together. The diagnosis was confirmed by high thallium concentrations in the blood and urine samples which were detected 8 to 12 d after exposure. We found that early treatment with the combination of hemoperfusion and Prussian blue significantly decreased the concentration of thallium in the body and improved the prognosis. Our study provided valuable experiences on early diagnosis and therapeutic regimen for thallium-poisoned patients.
Publish Date	2021-06-24 07:26
Citation	Wang TT, Wen B, Yu XN, Ji ZG, Sun YY, Li Y, Zhu SL, Cao YL, Wang M, Jian XD, Wang T. Early diagnosis, treatment, and outcomes of five patients with acute thallium poisoning. World J Clin Cases 2021; 9(19): 5082-5091
URL	https://www.wjgnet.com/2307-8960/full/v9/i19/5082.htm
DOI	https://dx.doi.org/10.12998/wjcc.v9.i19.5082

Full Article (PDF)	WJCC-9-5082.pdf
Full Article (Word)	WJCC-9-5082.docx
Manuscript File	63923_Auto_Edited-JPY_WangTQ.docx
Answering Reviewers	63923-Answering reviewers.pdf
Audio Core Tip	63923-Audio core tip.m4a
Biostatistics Review Certificate	63923-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	63923-Conflict-of-interest statement.pdf
Copyright License Agreement	63923-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	63923-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s)	63923-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	63923-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	63923-Language certificate.pdf
Peer-review Report	63923-Peer-review(s).pdf
Scientific Misconduct Check	63923-Bing-Fan JR-2.png
Scientific Misconduct Check	63923-Scientific misconduct check.pdf
Scientific Editor Work List	63923-Scientific editor work list.pdf