Publication Name	World Journal of Gastroenterology
Manuscript ID	64031
Country	Kazakhstan

Received	2021-02-07 14:59
Peer-Review Started	2021-02-07 15:05
To Make the First Decision
Return for Revision	2021-04-05 17:10
Revised	2021-04-13 09:53
Second Decision	2021-05-20 13:37
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2021-05-20 14:18
Articles in Press	2021-05-20 14:18
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-05-31 02:40
Typeset the Manuscript	2021-06-17 01:45
Publish the Manuscript Online	2021-07-06 02:31

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Immunology
Manuscript Type	Minireviews
Article Title	Autoimmune pancreatitis and pancreatic cancer: Epidemiological aspects and immunological considerations
Manuscript Source	Invited Manuscript
All Author List	Dimitri Poddighe
ORCID	Author(s) ORCID Number Dimitri Poddighe http://orcid.org/0000-0001-6431-9334
Funding Agency and Grant Number
Corresponding Author	Dimitri Poddighe, MD, MSc, PhD, Associate Professor, Director, Director, Doctor, Doctor, Department of Medicine, School of Medicine, Nazarbayev University, Kerei-Zhanibek Str. 5/1, Nur-Sultan 010000, Kazakhstan. dimitri.poddighe@nu.edu.kz
Key Words	Autoimmune pancreatitis; Chronic pancreatitis; Pancreatic cancer; Immunoglobulin G4-related disease; Epidemiology; Immunology; Basophils; Macrophages; Th2 cells; Systemic lupus erythematosus
Core Tip	This mini-review discusses the debated issue of autoimmune pancreatitis (type 1) as a potential risk factor for pancreatic cancer. After summarizing the few available (low-quality) epidemiological evidence that do not clearly support this role, the immunopathological characteristics of type 1 autoimmune pancreatitis (including Th2 immunological dominance, type 2 macrophage polarization and basophil infiltration) are discussed, as potential factors that may actually create a tolerogenic immunological environment favorable to pancreatic carcinogenesis and/or tumor progression.
Publish Date	2021-07-06 02:31
Citation	Poddighe D. Autoimmune pancreatitis and pancreatic cancer: Epidemiological aspects and immunological considerations. World J Gastroenterol 2021; 27(25): 3825-3836
URL	https://www.wjgnet.com/1007-9327/full/v27/i25/3825.htm
DOI	https://dx.doi.org/10.3748/wjg.v27.i25.3825

Full Article (PDF)	WJG-27-3825.pdf
Full Article (Word)	WJG-27-3825.docx
Manuscript File	64031-Review-Filipodia-CL.docx
Answering Reviewers	64031-Answering reviewers.pdf
Audio Core Tip	64031-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	64031-Conflict-of-interest statement.pdf
Copyright License Agreement	64031-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	64031-Language certificate.pdf
Peer-review Report	64031-Peer-review(s).pdf
Scientific Misconduct Check	64031-Bing-Yan JP-1.jpg
Scientific Misconduct Check	64031-Scientific misconduct check.pdf
Scientific Editor Work List	64031-Scientific editor work list.pdf
CrossCheck Report	64031-CrossCheck report.pdf