Publication Name	World Journal of Clinical Cases
Manuscript ID	64060
Country	China

Received	2021-02-08 12:50
Peer-Review Started	2021-02-08 12:53
To Make the First Decision
Return for Revision	2021-03-30 02:16
Revised	2021-04-02 08:16
Second Decision	2021-04-20 07:34
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2021-04-20 15:29
Articles in Press	2021-04-20 15:29
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-04-28 06:49
Typeset the Manuscript	2021-05-29 04:17
Publish the Manuscript Online	2021-06-11 09:22

ISSN	2307-8960 (online)
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Category	Gastroenterology & Hepatology
Manuscript Type	Case Report
Article Title	Growth hormone cocktail improves hepatopulmonary syndrome secondary to hypopituitarism: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Wen Ji, Min Nie, Jiang-Feng Mao, Hong-Bing Zhang, Xi Wang and Xue-Yan Wu
ORCID	Author(s) ORCID Number Wen Ji http://orcid.org/0000-0002-0871-6922 Min Nie http://orcid.org/0000-0002-4213-7123 Jiang-Feng Mao http://orcid.org/0000-0003-0157-1545 Hong-Bing Zhang http://orcid.org/0000-0001-6291-1027 Xi Wang http://orcid.org/0000-0002-8168-0233 Xue-Yan Wu http://orcid.org/0000-0002-9369-8430
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81771576 National Natural Science Foundation of China 81971375 Beijing Municipal Natural Science Foundation 7202151 Beijing Municipal Natural Science Foundation 7212080
Corresponding Author	Xue-Yan Wu, MD, Professor, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1 Shuai Fuyuan, Dong Cheng District, Beijing 100730, China. wsheyan@vip.sina.com
Key Words	Hepatopulmonary syndrome; Testosterone; Growth hormone; Intrapulmonary shunt; Insulin-like growth factor; Case report
Core Tip	Liver transplantation is currently known to be the only way to cure hepatopulmonary syndrome (HPS). Even after the successful transplantation surgery, metabolic associated fatty liver disease (MAFLD) always recurs in patients with hypopituitarism, who doesn’t receive appropriate hormone replacement therapy. We presented herein, a case of HPS (very severe) induced by panhypopituitarism was recovered by complete hormone replacement without surgery, especially growth hormone and testosterone. The case report highlights the importance of screening anterior pituitary function in patients with MAFLD or HPS as early as possible. The growth hormone cocktail therapy, especially growth hormone and testosterone, is expected to avoid liver transplantation.
Publish Date	2021-06-11 09:22
Citation	Ji W, Nie M, Mao JF, Zhang HB, Wang X, Wu XY. Growth hormone cocktail improves hepatopulmonary syndrome secondary to hypopituitarism: A case report. World J Clin Cases 2021; 9(18): 4852-4858
URL	https://www.wjgnet.com/2307-8960/full/v9/i18/4852.htm
DOI	https://dx.doi.org/10.12998/wjcc.v9.i18.4852

Full Article (PDF)	WJCC-9-4852.pdf
Full Article (Word)	WJCC-9-4852.docx
CARE Checklist–2016	64060-CARE-Checklist–2016-revision.jpeg
Manuscript File	64060_Auto_Edited_LM_WangTQ.docx
Answering Reviewers	64060-Answering reviewers.pdf
Audio Core Tip	64060-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	64060-Conflict-of-interest statement.pdf
Copyright License Agreement	64060-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	64060-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s)	64060-Informed consent statement.pdf
Non-Native Speakers of English Editing Certificate	64060-Language certificate.pdf
Peer-review Report	64060-Peer-review(s).pdf
Scientific Misconduct Check	64060-Scientific misconduct check.pdf
Scientific Editor Work List	64060-Scientific editor work list.pdf
CrossCheck Report	64060-CrossCheck report.pdf