Publication Name	World Journal of Hepatology
Manuscript ID	64068
Country	Greece

Received	2021-02-08 07:29
Peer-Review Started	2021-02-08 07:33
To Make the First Decision
Return for Revision	2021-04-06 06:38
Revised	2021-04-14 08:39
Second Decision	2021-12-31 03:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2021-12-31 22:24
Articles in Press	2021-12-31 22:24
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-12-19 22:32
Typeset the Manuscript	2022-01-18 04:34
Publish the Manuscript Online	2022-01-21 08:16

ISSN	1948-5182 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Hepatitis C virus: A critical approach to who really needs treatment
Manuscript Source	Invited Manuscript
All Author List	Elias Kouroumalis and Argryro Voumvouraki
ORCID	Author(s) ORCID Number Elias Kouroumalis http://orcid.org/0000-0002-6875-906X Argryro Voumvouraki http://orcid.org/0000-0002-2725-6028
Funding Agency and Grant Number
Corresponding Author	Elias Kouroumalis, MD, PhD, Emeritus Professor, Department of Gastroenterology, University of Crete Medical School, Voutes, Heraklion 71500, Crete, Greece. kouroumi@uoc.gr
Key Words	Hepatitis C, Comorbidities, Screening and treatment policy; Hepatitis C virus; Review
Core Tip	Elimination of hepatitis C virus (HCV) by 2030 according to the World Health Organization policy seems highly unlikely because of the funding re-direction due to the coronavirus disease 2019 pandemic. It is important therefore to re-evaluate the treatment policies based on a more realistic and feasible approach. HCV disease has a very prolonged natural course, and even HCV-related cirrhosis has a lower mortality compared to other cirrhosis etiologies. However, liver related morbidity and mortality is increased when certain comorbidities accompany the initial HCV infection. A review of the current knowledge allows for a more or less accurate identification of these comorbidities. Therefore, an eradication program is proposed based on screening and treating only these particular groups.
Publish Date	2022-01-21 08:16
Citation	Kouroumalis E, Voumvouraki A. HCV: Who really needs treatment. A critical approach. World J Hepatol 2022; 14(1): 1-44
URL	https://www.wjgnet.com/1948-5182/full/v14/i1/1.htm
DOI	https://dx.doi.org/10.4254/wjh.v14.i1.1

Full Article (PDF)	WJH-14-1.pdf
Full Article (Word)	WJH-14-1.docx
Manuscript File	64068_Auto_edited-ML-Filipodia.docx
Answering Reviewers	64068-Answering reviewers.pdf
Audio Core Tip	64068-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	64068-Conflict-of-interest statement.pdf
Copyright License Agreement	64068-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	64068-Language certificate.pdf
Peer-review Report	64068-Peer-review(s).pdf
Scientific Misconduct Check	64068-Bing-Liu M-2.PNG
Scientific Editor Work List	64068-Scientific editor work list.pdf
CrossCheck Report	64068-CrossCheck report.pdf