| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
PPARGC1A rs8192678 G>A polymorphism affects the severity of hepatic histological features and nonalcoholic steatohepatitis in patients with nonalcoholic fatty liver disease
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Rui-Nan Zhang, Feng Shen, Qin Pan, Hai-Xia Cao, Guang-Yu Chen and Jian-Gao Fan |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Key R&D Program of China |
2017YFC0908903 |
| National Natural Science Foundation of China |
81700503 |
| National Natural Science Foundation of China |
81873565 |
| National Natural Science Foundation of China |
81470840 |
| WBE Liver Fibrosis Foundation |
CFHPC2020061 |
| Hospital Funded Clinical Research, Clinical Research Unit, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine |
17CSK04 |
|
| Corresponding Author |
Jian-Gao Fan, MD, PhD, Director, Professor, Center for Fatty Liver, Department of Gastroenterology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Key Lab of Pediatric Gastroenterology and Nutrition, No. 1665 Kong Jiang Road, Yangpu District, Shanghai 200092, China. fanjiangao@xinhuamed.com.cn |
| Key Words |
Nonalcoholic fatty liver disease; Nonalcoholic steatohepatitis; PPARGC1A rs8192678 polymorphism; Steatosis; Activity |
| Core Tip |
The PPARGC1A rs8192678 A allele was found to be a risk factor for liver biopsy–proven nonalcoholic fatty liver disease (NAFLD) after adjusting for age, sex, and patatin-like phospholipase domain–containing protein 3 rs738409 polymorphism. The multivariate logistic regression analysis showed that the PPARGC1A rs8192678 risk A allele was also independently associated with the severity of hepatic histological features (S2-3 and A ≥ 2) and nonalcoholic steatohepatitis (NASH), and might also associate with nonobese NASH, indicating that the PPARGC1A rs8192678 risk A allele was associated with NAFLD in the Chinese Han adult population. Also, the intrahepatic expression of PPARGC1A mRNA was significantly lower in the patients who carried the risk A allele, implying that it might be a genetic contribution to the pathogenesis of NAFLD. |
| Publish Date |
2021-07-06 02:31 |
| Citation |
Zhang RN, Shen F, Pan Q, Cao HX, Chen GY, Fan JG. PPARGC1A rs8192678 G>A polymorphism affects the severity of hepatic histological features and nonalcoholic steatohepatitis in patients with nonalcoholic fatty liver disease. World J Gastroenterol 2021; 27(25): 3863-3876 |
| URL |
https://www.wjgnet.com/1007-9327/full/v27/i25/3863.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v27.i25.3863 |
