Publication Name	World Journal of Gastroenterology
Manuscript ID	6409
Country	Spain

Received	2013-10-17 14:26
Peer-Review Started	2013-10-18 13:51
To Make the First Decision	2014-01-15 12:21
Return for Revision	2014-01-20 12:29
Revised	2014-02-10 17:31
Second Decision	2014-04-03 10:15
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-04-03 12:30
Articles in Press	2014-05-23 10:16
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-07-17 11:08
Publish the Manuscript Online	2014-08-07 10:34

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Genetics & Heredity
Manuscript Type	Topic Highlights
Article Title	Genetic predisposition to colorectal cancer: Where we stand and future perspectives
Manuscript Source	Invited Manuscript
All Author List	Laura Valle
Funding Agency and Grant Number	Funding Agency Grant Number Spanish Ministry of the Economy (State Secretariat for Research, Development and Innovation) SAF2012-38885 Ramón y Cajal contract L’Oréal-UNESCO “For Women in Science” Scientific Foundation Asociación Española Contra el Cáncer
Corresponding Author	Laura Valle, PhD, Ramón y Cajal Researcher, Hereditary Cancer Program, Catalan Institute of Oncology, IDIBELL, Av. Gran Via 199-203, Hospitalet de Llobregat, 08908 Barcelona, Spain. lvalle@iconcologia.net
Key Words	Hereditary colorectal cancer; Familial colorectal cancer; High penetrance; Low penetrance; Cancer syndromes; Cancer susceptibility; Hereditary cancer genes; Risk variants; Heritability
Core Tip	The risk of developing colorectal cancer (CRC) can have genetic influences, especially when there is a family history of the disease. Much of this genetic predisposition to develop cancer is already known, including high-penetrance genes, i.e., those responsible for hereditary cases, and low-penetrance alleles, which are responsible for both sporadic and familial cases. However, despite recent developments in gene identification techniques, the genetic causes of many hereditary cases remain unknown. This review details the hereditary CRC syndromes and their genetic causes, the roles of low- and moderate-risk genetic factors in familial cases and the state-of-the-art in the identification of new causal genes.
Publish Date	2014-08-07 10:34
Citation	Valle L. Genetic predisposition to colorectal cancer: Where we stand and future perspectives. World J Gastroenterol 2014; 20(29): 9828-9849
URL	http://www.wjgnet.com/1007-9327/full/v20/i29/9828.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i29.9828

Full Article (PDF)	WJG-20-9828.pdf
Full Article (Word)	WJG-20-9828.doc
Manuscript File	6409-Review.doc
Answering Reviewers	6409-Answering reviewers.pdf
Copyright License Agreement	6409-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	6409-Language certificate.pdf
Peer-review Report	6409-Peer reviews.pdf
Scientific Editor Work List	6409-Scientific editor work list.doc