Publication Name	World Journal of Critical Care Medicine
Manuscript ID	64157
Country	United States

Received	2021-02-09 23:57
Peer-Review Started	2021-02-10 00:00
To Make the First Decision
Return for Revision	2021-03-31 05:30
Revised	2021-04-13 19:03
Second Decision	2021-06-02 11:21
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2021-06-02 13:03
Articles in Press	2021-06-02 13:03
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-07-05 06:23
Publish the Manuscript Online	2021-07-06 23:59

ISSN	2220-3141(online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Critical Care Medicine
Manuscript Type	Review
Article Title	Sepsis: Evidence-based pathogenesis and treatment
Manuscript Source	Invited Manuscript
All Author List	Jay Pravda
ORCID	Author(s) ORCID Number Jay Pravda http://orcid.org/0000-0001-5737-5506
Funding Agency and Grant Number
Corresponding Author	Jay Pravda, MD, Research Scientist, Inflammatory Disease Research Centre, Therashock LLC, 4371 Northlake Blvd No. 247, Palm Beach Gardens, FL 33410, United States. jaypravda1@gmail.com
Key Words	Sepsis; Septic shock; Redox homeostasis; Thiosulfate; Hydrogen peroxide
Core Tip	Sepsis mortality remains unacceptably high because there is no specific treatment to prevent or reverse the multiple organ failure and refractory hypotension that develops in this condition. An evidence-based analysis suggests that a hypermetabolic state leading to a system-wide impaired redox homeostasis and subsequent toxic systemic accumulation of hydrogen peroxide (H2O2) has a causal role in the pathogenesis of this often fatal illness. The data imply that restoration of redox homeostasis by therapeutic reduction of H2O2 will significantly reduce the morbidity and mortality associated with sepsis. A therapeutic intervention to reduce systemic levels of H2O2 is presented in this paper.
Publish Date	2021-07-06 23:59
Citation	Pravda J. Sepsis: Evidence-based pathogenesis and treatment. World J Crit Care Med 2021; 10(4): 66-80
URL	https://www.wjgnet.com/2220-3141/full/v10/i4/66.htm
DOI	https://dx.doi.org/ 10.5492/wjccm.v10.i4.66

Full Article (PDF)	WJCCM-10-66.pdf
Full Article (Word)	WJCCM-10-66.docx
Manuscript File	64157_Auto_Edited-ZMG.docx
Answering Reviewers	64157-Answering reviewers.pdf
Audio Core Tip	64157-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	64157-Conflict-of-interest statement.pdf
Copyright License Agreement	64157-Copyright license agreement.pdf
Peer-review Report	64157-Peer-review(s).pdf
Scientific Misconduct Check	64157-Scientific misconduct check.pdf
Scientific Editor Work List	64157-Scientific editor work list.pdf
CrossCheck Report	64157-CrossCheck report.pdf