Publication Name	World Journal of Gastroenterology
Manuscript ID	6419
Country	China

Received	2013-10-17 15:53
Peer-Review Started	2013-10-18 15:05
First Decision by Editorial Office Director
Return for Revision	2013-11-14 16:11
Revised	2013-11-17 18:18
Publication Fee Transferred
Second Decision by Editor	2014-01-02 10:56
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2014-01-02 12:03
Articles in Press
Edit the Manuscript by Language Editor	2014-03-25 19:08
Typeset the Manuscript	2014-04-16 19:12
Publish the Manuscript Online	2014-04-29 09:53

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Combined probiotic bacteria promotes intestinal epithelial barrier function in interleukin-10-gene-deficient mice
Manuscript Source	Invited Manuscript
All Author List	Chen-Zhang Shi, Hong-Qi Chen, Yong Liang, Yang Xia, Yong-Zhi Yang, Jun Yang, Jun-Dong Zhang, Shu-Hai Wang, Jing Liu and Huan-Long Qin
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation Key Projects of China 81230057 National Natural Science Foundation of China 81172325 Major Basic Research Program of Shanghai 12DZ1930502
Corresponding Author	Huan-Long Qin, MD, Professor, Department of Surgery, Affiliated Sixth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Jiao Tong University, 600 Yishan Road, Shanghai 200233, China. hlqin10@163.com
Key Words	Probiotic bacteria; Intestinal barrier function; Tight junction proteins; Interleukin-10 gene-deficient mice; Caco-2 monolayers
Core Tip	We investigated the protective effects of combinations of probiotic bacteria (Bifico) on interleukin (IL)-10 gene-deficient (IL-10 KO) mice and Caco-2 cell monolayers. Treatment of IL-10 KO mice with Bifico partially restored body weight, colon length, and epithelial barrier integrity to wild-type levels. Treatment of Caco-2 monolayers with Bifico or single-strain probiotics inhibited enteroinvasive Escherichia coli (EIEC) invasion and reduced secretion of proinflammatory cytokines. Oral administration of Bifico reduced colon inflammation, and directly promoted epithelial barrier function. In addition, Bifico improved epithelial barrier function, and enhanced resistance to EIEC invasion in vitro.
Publish Date	2014-04-29 09:53
Citation	Shi CZ, Chen HQ, Liang Y, Xia Y, Yang YZ, Yang J, Zhang JD, Wang SH, Liu J, Qin HL. Combined probiotic bacteria promotes intestinal epithelial barrier function in interleukin-10-gene-deficient mice. World J Gastroenterol 2014; 20(16): 4636-4647
URL	http://www.wjgnet.com/1007-9327/full/v20/i16/4636.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i16.4636

Full Article (PDF)	WJG-20-4636.pdf
Full Article (Word)	WJG-20-4636.doc
Manuscript File	6419-Review.doc
Answering Reviewers	6419-Answering reviewers.pdf
Copyright License Agreement	6419-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	6419-Language certificate.pdf
Peer-review Report	6419-Peer review(s).pdf
Scientific Editor Work List	6419-Scientific editor work list.doc