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Articles Published Processes
6/26/2021 7:48:01 AM | Browse: 586 | Download: 914
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Received |
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2021-02-12 00:08 |
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Peer-Review Started |
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2021-02-12 00:12 |
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To Make the First Decision |
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Return for Revision |
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2021-03-17 01:19 |
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Revised |
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2021-03-27 17:42 |
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Second Decision |
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2021-05-27 06:38 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-05-27 09:48 |
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Articles in Press |
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2021-05-27 09:48 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2021-06-04 02:28 |
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Typeset the Manuscript |
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2021-06-23 12:17 |
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Publish the Manuscript Online |
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2021-06-26 07:48 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Heat shock protein 20 promotes sirtuin-1-dependent cellular proliferation in induced pluripotent stem cells
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Mujib Ullah, Nicole Pek Min Qian, Gustavo Yannarelli and Asma Akbar |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Mujib Ullah, MD, PhD, Doctor, Doctor, Institute for Immunity and Transplantation, Stem Cell Biology and Regenerative Medicine, School of Medicine, Stanford University, Stanford , CA 94304, United States. ullah@stanford.edu |
| Key Words |
Heat shock proteins; Stem cells; Proliferation; Induced pluripotent stem cells; Sirtuin-1; Heat shock protein 20; Pluripotency |
| Core Tip |
Heat shock proteins (HSPs) are housekeeper proteins, guarding cells against injury and damage response. HSPs send signals from diseased or damaged cells to the immune system’s which activates the body defense system. Subsequently, the body defense system releases inflammatory signals to recruit other immune cells and kills the pathogen in case of infection or repair the cells in case of damage. HSPs trigger a cascade of events that involve essential proteins to accelerate the repair process or degrade injured protein as a protection plan to ensure survival. How HSPs respond to stress or injury stimulus is a question of further investigation. Accumulating evidence indicates that HSP20 is associated with cellular proliferation. However, the precise mechanisms by which HSP20 promotes stem cell proliferation remain unclear. Herein, we established a distinct cross-talk between HSP20 and sirtuin-1 in regulating cellular proliferation. Our study can open a new avenue for the drug discovery and treatment of critical diseases. |
| Publish Date |
2021-06-26 07:48 |
| Citation |
Ullah M, Qian NPM, Yannarelli G, Akbar A. Heat shock protein 20 promotes sirtuin-1-dependent cellular proliferation in induced pluripotent stem cell. World J Stem Cells 2021; 13(6): 659-669 |
| URL |
https://www.wjgnet.com/1948-0210/full/v13/i6/659.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v13.i6.659 |
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