Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	64250
Country	China

Received	2021-02-20 13:47
Peer-Review Started	2021-02-20 13:57
To Make the First Decision
Return for Revision	2021-07-29 02:51
Revised	2021-08-04 14:55
Second Decision	2021-10-26 07:59
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2021-10-27 03:27
Articles in Press	2021-10-27 03:27
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-12-07 04:34
Publish the Manuscript Online	2021-12-14 23:58

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Minireviews
Article Title	Advancement of chimeric antigen receptor-natural killer cells targeting hepatocellular carcinoma
Manuscript Source	Invited Manuscript
All Author List	Kai Dai, Yin Wu, Sha She and Qian Zhang
ORCID	Author(s) ORCID Number Kai Dai http://orcid.org/0000-0001-7270-9965 Yin Wu http://orcid.org/0000-0002-0987-2097 Sha She http://orcid.org/0000-0002-1863-957X Qian Zhang http://orcid.org/0000-0003-1053-1588
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China (General Program) 81972673
Corresponding Author	Kai Dai, MD, PhD, Doctor, Doctor, Department of Infectious Diseases, Renmin Hospital of Wuhan University, No.238,Jie Fang Road,Wuchang District, Wuhan 430060, Hubei Province, China. daikai@whu.edu.cn
Key Words	Chimeric antigen receptors; Natural killer cells; Hepatocellular carcinoma; Immunotherapy; Genome engineering
Core Tip	Chimeric antigen receptors (CARs)-based immunotherapy is an emerging therapeutic strategy for tumors. This review summarizes the recent advances in genetic engineering of CAR-natural killer (NK) cells against hepatocellular carcinoma and discuss the current challenges and prospects of CAR-NK cells as a revolutionary cellular immunotherapy against hepatocellular carcinoma.
Publish Date	2021-12-14 23:58
Citation	Dai K, Wu Y, She S, Zhang Q. Advancement of chimeric antigen receptor-natural killer cells targeting hepatocellular carcinoma. World J Gastrointest Oncol 2021; 13(12): 2029-2037
URL	https://www.wjgnet.com/1948-5204/full/v13/i12/2029.htm
DOI	https://dx.doi.org/10.4251/wjgo.v13.i12.2029

Full Article (PDF)	WJGO-13-2029.pdf
Full Article (Word)	WJGO-13-2029.docx
Manuscript File	64250_Auto_Edited.docx
Answering Reviewers	64250-Answering reviewers.pdf
Audio Core Tip	64250-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	64250-Conflict-of-interest statement.pdf
Copyright License Agreement	64250-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	64250-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	64250-Language certificate.pdf
Peer-review Report	64250-Peer-review(s).pdf
Scientific Misconduct Check	64250-Bing-Wang LL-2.png
Scientific Editor Work List	64250-Scientific editor work list.pdf
CrossCheck Report	64250-CrossCheck report.pdf