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Articles Published Processes
10/13/2021 8:37:10 AM | Browse: 617 | Download: 1608
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Received |
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2021-02-25 03:02 |
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Peer-Review Started |
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2021-02-25 03:05 |
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First Decision by Editorial Office Director |
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2021-06-23 14:24 |
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Return for Revision |
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2021-06-23 14:24 |
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Revised |
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2021-07-28 00:22 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2021-08-30 03:28 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2021-08-30 07:29 |
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Articles in Press |
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2021-08-30 07:29 |
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Edit the Manuscript by Language Editor |
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2021-09-12 02:58 |
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Typeset the Manuscript |
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2021-10-11 04:19 |
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Publish the Manuscript Online |
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2021-10-13 08:37 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Minireviews |
| Article Title |
Tale of two kinases: Protein kinase A and Ca2+/calmodulin-dependent protein kinase II in pre-diabetic cardiomyopathy
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Pamela Gaitán-González, Rommel Sánchez-Hernández, José-Antonio Arias-Montaño and Angélica Rueda |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| SEP-Cinvestav Project |
FIDSC 2018/2 |
| SEP-Conacyt Ciencia Básica 2017-2018 |
A1-S-9082 |
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| Corresponding Author |
Angélica Rueda, PhD, Professor, Department of Biochemistry, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Av. IPN 2508, San Pedro Zacatenco, Ciudad de México 07360, Mexico. arueda@cinvestav.mx |
| Key Words |
Ca2+/calmodulin-dependent protein kinase II; Protein kinase A; Metabolic syndrome; Pre-diabetes; Pre-diabetic cardiomyopathy; β-Adrenoceptors |
| Core Tip |
Metabolic syndrome affects heart function leading to pre-diabetic cardiomyopathy. In an attempt to overcome contractility dysfunction, the activity of the sympathetic nervous system increases, but chronic stimulation of β-adrenoceptors leads to alterations in both protein kinase A (PKA) and Ca2+/calmodulin-dependent protein kinase II (CaMKII) activity, the main effectors of the β-adrenergic response. This work recapitulates current evidence about the participation of PKA and CaMKII in experimental pre-diabetic cardiomyopathy, emphasizing the prevailing role of CaMKII in the development of cardiomyocyte Ca2+ mishandling and myocardial dysfunction associated with pre-diabetes. |
| Publish Date |
2021-10-13 08:37 |
| Citation |
Gaitán-González P, Sánchez-Hernández R, Arias-Montaño JA, Rueda A. Tale of two kinases: Protein kinase A and Ca2+/calmodulin-dependent protein kinase II in pre-diabetic cardiomyopathy. World J Diabetes 2021; 12(10): 1704-1718 |
| URL |
https://www.wjgnet.com/1948-9358/full/v12/i10/1704.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v12.i10.1704 |
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