Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	64313
Country	Croatia

Received	2021-02-14 22:21
Peer-Review Started	2021-02-14 22:25
To Make the First Decision
Return for Revision	2021-03-16 17:05
Revised	2021-03-22 08:25
Second Decision	2021-08-06 03:17
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2021-08-06 06:14
Articles in Press	2021-08-06 06:14
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-09-17 13:05
Publish the Manuscript Online	2021-09-18 13:32

ISSN	1948-9366 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	How can probiotic improve irritable bowel syndrome symptoms?
Manuscript Source	Invited Manuscript
All Author List	Indira Benjak Horvat, Ivana Gobin, Andrea Kresović and Goran Hauser
ORCID	Author(s) ORCID Number Indira Benjak Horvat http://orcid.org/0000-0002-9740-3310 Ivana Gobin http://orcid.org/0000-0002-8956-4675 Andrea Kresović http://orcid.org/0000-0001-7570-3139 Goran Hauser http://orcid.org/0000-0002-4758-1717
Funding Agency and Grant Number
Corresponding Author	Ivana Gobin, PhD, Associate Professor, Department of Microbiology and Parasitology, Faculty of Medicine, University of Rijeka, Braće Branchetta 20, Rijeka 51000, Croatia. ivana.gobin@uniri.hr
Key Words	Irritable bowel syndrome; Obstipation; Diarrhoea; Abdominal pain; Probiotic; Prebiotic; Symbiotic; Microbiota
Core Tip	The onset and manifestations of irritable bowel syndrome (IBS) is associated with a number of factors, and the pathophysiology involves various central and peripheral mechanisms. The results of most studies indicate that influencing the gut microbiota could significantly affect the improvement of subjective disorders in patients with IBS. The most important open questions are the design of a clinical study in which the IBS subgroup is not initially defined and whether all IBS subtypes can be treated with the same probiotic or combination of probiotics. IBS subtype-designed clinical studies are urgently needed as a good foundation to define recommendations and guidelines for the use of probiotics in IBS.
Publish Date	2021-09-18 13:32
Citation	Benjak Horvat I, Gobin I, Kresović A, Hauser G. How can probiotic improve irritable bowel syndrome symptoms? World J Gastrointest Surg 2021; 13(9): 923-940
URL	https://www.wjgnet.com/1948-9366/full/v13/i9/923.htm
DOI	https://dx.doi.org/10.4240/wjgs.v13.i9.923

Full Article (PDF)	WJGS-13-923.pdf
Full Article (Word)	WJGS-13-923.docx
Manuscript File	64313_Auto_Edited-JPY.docx
Answering Reviewers	64313-Answering reviewers.pdf
Audio Core Tip	64313-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	64313-Conflict-of-interest statement.pdf
Copyright License Agreement	64313-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	64313-Language certificate.pdf
Peer-review Report	64313-Peer-review(s).pdf
Scientific Misconduct Check	64313-Scientific misconduct check.pdf
Scientific Editor Work List	64313-Scientific editor work list.pdf
CrossCheck Report	64313-CrossCheck report.pdf