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Articles Published Processes
12/27/2021 5:24:00 AM | Browse: 481 | Download: 1086
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Received |
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2021-05-04 16:36 |
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Peer-Review Started |
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2021-05-04 16:38 |
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To Make the First Decision |
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Return for Revision |
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2021-06-17 20:11 |
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Revised |
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2021-06-21 23:26 |
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Second Decision |
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2021-10-26 07:59 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-10-27 03:22 |
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Articles in Press |
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2021-10-27 03:22 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2021-10-15 22:42 |
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Typeset the Manuscript |
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2021-12-13 08:53 |
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Publish the Manuscript Online |
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2021-12-27 05:24 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Observational Study |
| Article Title |
New stem cell autophagy surrogate diagnostic biomarkers in early-stage hepatocellular carcinoma in Egypt: A pilot study
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Tarek Yosef, Wesam Ahmed Ibrahim, Marwa Matboli, Amina Ahmed Swilam and Sarah El-Nakeep |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
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| Corresponding Author |
Sarah El-Nakeep, MD, Associate Professor, Gastroenterology and Hepatology Unit, Department of Internal Medicine, Faculty of Medicine, Ain Shams University, Ramsees Street, Cairo 11591, Egypt. sarahnakeep@gmail.com |
| Key Words |
Autophagy; Hepatocellular carcinoma; miRNA; miR-519d; Stem cell; SQSTM1 |
| Core Tip |
Hepatocellular carcinoma (HCC) is the most common primary liver cancer. HCC is associated with poor prognosis due to difficult discovery at an early stage. The molecular pathophysiology behind HCC is not yet fully understood. Autophagy is one of the important affected pathways in HCC pathogenesis. In this study we used Insilco analysis to determine a new molecular pathway and find the background controlling genetic and epigentic pathways underlying. We found that autophagy-controlling gene SQSTM1 is related to hsa-miR-519d-3p. Also, we found that their use as early detecting biomarkers for HCC diagnosis are more efficient than the current alpha-fetoprotein. |
| Publish Date |
2021-12-27 05:24 |
| Citation |
Yosef T, Ibrahim WA, Matboli M, Swilam AA, El-Nakeep S. New stem cell autophagy surrogate diagnostic biomarkers in early-stage hepatocellular carcinoma in Egypt: A pilot study. World J Hepatol 2021; 13(12): 2137-2149 |
| URL |
https://www.wjgnet.com/1948-5182/full/v13/i12/2137.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v13.i12.2137 |
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