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9/5/2014 2:54:00 PM | Browse: 384 | Download: 361
Publication Name World Journal of Gastrointestinal Pharmacology and Therapeutics
Manuscript ID 6435
Country/Territory Italy
Received
2013-10-18 09:47
Peer-Review Started
2013-10-21 11:55
To Make the First Decision
2013-12-25 18:03
Return for Revision
2014-01-02 15:29
Revised
2014-01-20 20:07
Second Decision
2014-02-19 11:18
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-02-19 11:42
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
2014-03-14 04:53
Typeset the Manuscript
2014-05-08 20:28
Publish the Manuscript Online
2014-05-20 15:49
ISSN 2150-5349 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Autobiography
Article Title Understanding and treating refractory constipation
Manuscript Source Invited Manuscript
All Author List Gabrio Bassotti and Corrado Blandizzi
Funding Agency and Grant Number
Corresponding author Gabrio Bassotti, Professor, Gastroenterology and Hepatology Section, Department of Medicine, University of Perugia, Ospedale Santa Maria della Misericordia, Piazzale Menghini 1, 06156 Perugia, Italy. gabassot@tin.it
Keywords Chronic constipation; Laxatives; Medical treatment; Refractory constipation; Surgical treatment
Core Tip The majority of patients affected by chronic constipation can be managed by conventional therapeutic approaches. However, a subset of constipated patients displays a condition of actual refractoriness to standard medical treatment, even after careful clinical re-evaluation. These patients require more in-depth diagnostic evaluations to ascertain the underlying pathophysiological mechanisms, as well as more intensive, targeted and tailored therapeutic approaches, which may rely on the use of newly released drugs (enterokinetics, enteric secretagogues), rehabilitation (biofeedback), invasive measures (sacral neuromodulation, local injection of botulinum toxin, antegrade continence enemas) and surgical procedures (subtotal colectomy with ileorectal anastomosis or stapled transanal rectal resection).
Publish Date 2014-05-20 15:49
Citation Bassotti G, Blandizzi C. Understanding and treating refractory constipation. World J Gastrointest Pharmacol Ther 2014; 5(2): 77-85
Url http://www.wjgnet.com/2150-5349/full/v5/i2/77.htm
DOI http://dx.doi.org/10.4292/wjgpt.v5.i2.77
Full Article (PDF) WJGPT-5-77.pdf
Full Article (Word) WJGPT-5-77.doc
Manuscript File 6435-Review.doc
Answering Reviewers 6435-Answering reviewers.pdf
Copyright License Agreement 6435-Copyright assignment.pdf
Peer-review Report 6435-Peer reviewer(s).pdf
Scientific Editor Work List 6435-Scientific editor work list.doc