Publication Name	World Journal of Transplantation
Manuscript ID	64371
Country	Japan

Received	2021-02-16 07:45
Peer-Review Started	2021-02-16 07:50
To Make the First Decision
Return for Revision	2021-05-14 00:21
Revised	2021-05-25 07:37
Second Decision	2021-08-10 03:00
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2021-08-10 06:05
Articles in Press	2021-08-10 06:05
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-08-12 00:32
Publish the Manuscript Online	2021-08-12 09:45

ISSN	2220-3230 (online)
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Category	Transplantation
Manuscript Type	Minireviews
Article Title	Biomarkers of graft-vs-host disease: Understanding and applications for the future
Manuscript Source	Invited Manuscript
All Author List	Masayuki Nagasawa
ORCID	Author(s) ORCID Number Masayuki Nagasawa http://orcid.org/0000-0002-8085-4940
Funding Agency and Grant Number	Funding Agency Grant Number Grant-in-Aid for Scientific Research (KAKENHI) Grant 15K09639
Corresponding Author	Masayuki Nagasawa, MD, PhD, Chief Doctor, Department of Pediatrics, Musashino Red Cross Hospital, 1-26-1, Kyonan-cho, Musashino City 180-8610, Tokyo, Japan. mnagasawa.ped@tmd.ac.jp
Key Words	Graft-vs-host disease; Hematopoietic stem cell transplantation; Biomarker; Cytokine; Graft-vs-host reaction; Organ damage
Core Tip	Graft-vs-host disease (GVHD) is the most unfavorable complication of hematopoietic stem cell transplantation (HSCT). Minimizing acute GVHD and inducing its chronic form is necessary to achieve good clinical outcomes in HSCT. GVHD consists of inflammation induced by the conditioning regimen, the alloimmune response of the T lymphocytes, and organ damage due to the graft-vs-host reaction. Biological factors have been comprehensively analyzed to identify novel combinations of biomarkers that predict acute GVHD severity and prognosis more efficiently. Currently, there are no useful biomarkers that can predict the severity and prognosis of chronic GVHD or serve a practical clinical use.
Publish Date	2021-08-12 09:45
Citation	Nagasawa M. Biomarkers of graft-vs-host disease: Understanding and applications for the future. World J Transplant 2021;11(8): 335-343
URL	https://www.wjgnet.com/2220-3230/full/v11/i8/335.htm
DOI	https://dx.doi.org/10.5500/wjt.v11.i8.335

Full Article (PDF)	WJT-11-335.pdf
Full Article (Word)	WJT-11-335.docx
Manuscript File	64371_Auto_Edited-JPY.docx
Answering Reviewers	64371-Answering reviewers.pdf
Audio Core Tip	64371-Audio core tip.MP3
Conflict-of-Interest Disclosure Form	64371-Conflict-of-interest statement.pdf
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Non-Native Speakers of English Editing Certificate	64371-Language certificate.pdf
Peer-review Report	64371-Peer-review(s).pdf
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Scientific Misconduct Check	64371-Scientific misconduct check.pdf
Scientific Editor Work List	64371-Scientific editor work list.pdf
CrossCheck Report	64371-CrossCheck report.pdf