Publication Name	World Journal of Hepatology
Manuscript ID	6438
Country	United States

Received	2013-10-18 10:19
Peer-Review Started	2013-10-21 14:25
To Make the First Decision	2014-02-13 16:29
Return for Revision	2014-02-19 16:03
Revised	2014-02-25 21:55
Second Decision	2014-03-18 14:57
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-03-18 15:18
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-05-08 20:33
Publish the Manuscript Online	2014-05-20 15:05

ISSN	1948-5182 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Pediatric non-alcoholic fatty liver disease: New insights and future directions
Manuscript Source	Invited Manuscript
All Author List	Pierluigi Marzuillo, Emanuele Miraglia del Giudice and Nicola Santoro
Funding Agency and Grant Number	Funding Agency Grant Number American Heart Association (AHA) 13SDG14640038 2012 Yale Center for Clinical Investigation (YCCI) scholar to Santoro N National Center for Advancing Translational Science (NCATS), a component of the National Institutes of Health (NIH), and NIH roadmap for Medical Research UL1 RR024139
Corresponding Author	Nicola Santoro, MD, PhD, Department of Pediatrics, Yale University School of Medicine, 330 Cedar Street, P.O. Box 208064, New Haven, CT 06520, United States. nicola.santoro@yale.edu
Key Words	Non alcoholic fatty liver disease; PNPLA3; Obesity; Insulin resistance; Glucokinase regulatory protein; Fructose
Core Tip	The prevalence of hepatic steatosis is increased in the last three decades concomitantly with the increased prevalence of pediatric obesity. Non-alcoholic fatty liver disease (NAFLD) is the most common form of liver disease in children. The PNPLA3 rs738409 and the glucokinase regulatory protein rs1260326 are the strongest variants associated with fatty liver in paediatrics. Important risk factors are obesity, insulin resistence, gender, ethnicity and excessive dietetic intake of n-6 polyunsatured fatty acids and fructose. New pharmacological approaches are object of study, in NAFLD children poorly adherent to or being unresponsive/partially responsive to lifestyle changes.
Publish Date	2014-05-20 15:05
Citation	Marzuillo P, Miraglia del Giudice E, Santoro N. Pediatric non-alcoholic fatty liver disease: New insights and future directions. World J Hepatol 2014; 6(4): 217-225
URL	http://www.wjgnet.com/1948-5182/full/v6/i4/217.htm
DOI	http://dx.doi.org/10.4254/wjh.v6.i4.217

Full Article (PDF)	WJH-6-217.pdf
Full Article (Word)	WJH-6-217.doc
Manuscript File	6438-Review.doc
Answering Reviewers	6438-Asnwering reviewers.pdf
Copyright License Agreement	6438-Copyright assignment.pdf
Peer-review Report	6438-Peer reviewer(s).pdf
Scientific Editor Work List	6438-Scientific editor work list.doc