Publication Name	World Journal of Gastroenterology
Manuscript ID	64399
Country	Spain

Received	2021-02-16 16:37
Peer-Review Started	2021-02-16 16:42
To Make the First Decision
Return for Revision	2021-05-01 23:25
Revised	2021-05-13 14:59
Second Decision	2021-07-09 03:28
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2021-07-09 12:06
Articles in Press	2021-07-09 12:06
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-07-20 14:28
Typeset the Manuscript	2021-08-06 10:30
Publish the Manuscript Online	2021-08-10 06:48

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Prospective Study
Article Title	Naïve hepatitis B e antigen-negative chronic hepatitis B patients are at risk of carotid atherosclerosis: A prospective study
Manuscript Source	Unsolicited Manuscript
All Author List	Mar Riveiro-Barciela, Cristina Marcos-Fosch, Fernando Martinez-Valle, Fabrizio Bronte, Olimpia Orozco, Isidro Sanz-Pérez, Daniele Torres, Maria-Teresa Salcedo, Salvatore Petta, Rafael Esteban, Antonio Craxi and Maria Buti
ORCID	Author(s) ORCID Number Mar Riveiro-Barciela http://orcid.org/0000-0001-9309-2052 Cristina Marcos-Fosch http://orcid.org/0000-0003-0130-2273 Fernando Martinez-Valle http://orcid.org/0000-0003-2673-2034 Fabrizio Bronte http://orcid.org/0000-0003-0896-830X Olimpia Orozco http://orcid.org/0000-0002-3527-7195 Isidro Sanz-Pérez http://orcid.org/0000-0002-4903-7600 Daniele Torres http://orcid.org/0000-0002-8399-4957 Maria-Teresa Salcedo http://orcid.org/0000-0002-4822-5060 Salvatore Petta http://orcid.org/0000-0002-0822-9673 Rafael Esteban http://orcid.org/0000-0001-5280-392X Antonio Craxi http://orcid.org/0000-0002-4480-9544 Maria Buti http://orcid.org/0000-0002-0732-3078
Funding Agency and Grant Number	Funding Agency Grant Number IV Fellowship Gilead-Research projects in HIV and hepatitis funded by Gilead Science GLD16_00057
Corresponding Author	Maria Buti, MD, PhD, Chief Doctor, Full Professor, Senior Scientist, Department of Medicine of the UAB, Hospital Universitari Vall d'Hebron, Passeig Vall d'Hebrón 119-129, General Hospital Building, Hepatology Unit, Barcelona 08035, Spain. mbuti@vhebron.net
Key Words	Hepatitis B virus; Carotid plaques; Subclinical atherosclerosis; Cardiovascular risk; Endothelial dysfunction; Intima-media thickness
Core Tip	Prospective case-control collaborative study that aimed to assess whether chronic infection by hepatitis B was associated with risk of carotid plaques and subclinical atherosclerosis. Overall, 402 subjects were recruited, 201 naïve hepatitis B e antigen (HBeAg)-negative hepatitis B virus-infected and 201 healthy controls. Subclinical atherosclerosis was established on an intima-media thickness increase of ≥ 1.2 mm and/or the presence of carotid plaques. Patients with HBeAg negative chronic hepatitis B presented higher rate of carotid plaques than non-infected controls but no differences were observed between controls and hepatitis B inactive carriers. These results suggest that hepatitis B infection may have a role as a cardiovascular risk factor in patients with chronic hepatitis B.
Publish Date	2021-08-10 06:48
Citation	Riveiro-Barciela M, Marcos-Fosch C, Martinez-Valle F, Bronte F, Orozco O, Sanz-Pérez I, Torres D, Salcedo MT, Petta S, Esteban R, Craxi A, Buti M. Naïve hepatitis B e antigen-negative chronic hepatitis B patients are at risk of carotid atherosclerosis: A prospective study. World J Gastroenterol 2021; 27(30): 5112-5125
URL	https://www.wjgnet.com/1007-9327/full/v27/i30/5112.htm
DOI	https://dx.doi.org/10.3748/wjg.v27.i30.5112

Full Article (PDF)	WJG-27-5112.pdf
Full Article (Word)	WJG-27-5112.docx
Manuscript File	64399_Review-Filipodiav1CL.docx
Answering Reviewers	64399-Answering reviewers.pdf
Audio Core Tip	64399-Audio core tip.mp3
Biostatistics Review Certificate	64399-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	64399-Conflict-of-interest statement.pdf
Copyright License Agreement	64399-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	64399-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s)	64399-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	64399-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	64399-Language certificate.pdf
Supplementary Material	64399-Supplementary material.pdf
Peer-review Report	64399-Peer-review(s).pdf
Scientific Misconduct Check	64399-Scientific misconduct check.pdf
Scientific Editor Work List	64399-Scientific editor work list.pdf
CrossCheck Report	64399-CrossCheck report.pdf