| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Prospective Study |
| Article Title |
Naïve hepatitis B e antigen-negative chronic hepatitis B patients are at risk of carotid atherosclerosis: A prospective study
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Mar Riveiro-Barciela, Cristina Marcos-Fosch, Fernando Martinez-Valle, Fabrizio Bronte, Olimpia Orozco, Isidro Sanz-Pérez, Daniele Torres, Maria-Teresa Salcedo, Salvatore Petta, Rafael Esteban, Antonio Craxi and Maria Buti |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| IV Fellowship Gilead-Research projects in HIV and hepatitis funded by Gilead Science |
GLD16_00057 |
|
| Corresponding Author |
Maria Buti, MD, PhD, Chief Doctor, Full Professor, Senior Scientist, Department of Medicine of the UAB, Hospital Universitari Vall d'Hebron, Passeig Vall d'Hebrón 119-129, General Hospital Building, Hepatology Unit, Barcelona 08035, Spain. mbuti@vhebron.net |
| Key Words |
Hepatitis B virus; Carotid plaques; Subclinical atherosclerosis; Cardiovascular risk; Endothelial dysfunction; Intima-media thickness |
| Core Tip |
Prospective case-control collaborative study that aimed to assess whether chronic infection by hepatitis B was associated with risk of carotid plaques and subclinical atherosclerosis. Overall, 402 subjects were recruited, 201 naïve hepatitis B e antigen (HBeAg)-negative hepatitis B virus-infected and 201 healthy controls. Subclinical atherosclerosis was established on an intima-media thickness increase of ≥ 1.2 mm and/or the presence of carotid plaques. Patients with HBeAg negative chronic hepatitis B presented higher rate of carotid plaques than non-infected controls but no differences were observed between controls and hepatitis B inactive carriers. These results suggest that hepatitis B infection may have a role as a cardiovascular risk factor in patients with chronic hepatitis B. |
| Publish Date |
2021-08-10 06:48 |
| Citation |
Riveiro-Barciela M, Marcos-Fosch C, Martinez-Valle F, Bronte F, Orozco O, Sanz-Pérez I, Torres D, Salcedo MT, Petta S, Esteban R, Craxi A, Buti M. Naïve hepatitis B e antigen-negative chronic hepatitis B patients are at risk of carotid atherosclerosis: A prospective study. World J Gastroenterol 2021; 27(30): 5112-5125 |
| URL |
https://www.wjgnet.com/1007-9327/full/v27/i30/5112.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v27.i30.5112 |
