Publication Name	World Journal of Clinical Cases
Manuscript ID	64426
Country	Italy

Received	2021-02-18 10:10
Peer-Review Started	2021-02-18 10:14
To Make the First Decision
Return for Revision	2021-03-22 11:40
Revised	2021-03-26 15:50
Second Decision	2021-06-28 12:43
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-06-28 12:50
Articles in Press	2021-06-28 12:50
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-07-21 14:02
Publish the Manuscript Online	2021-07-28 01:52

ISSN	2307-8960 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Role of autophagy in cholangiocarcinoma: Pathophysiology and implications for therapy
Manuscript Source	Invited Manuscript
All Author List	Elisabetta Ninfole, Claudio Pinto, Antonio Benedetti, Marco Marzioni and Luca Maroni
ORCID	Author(s) ORCID Number Elisabetta Ninfole http://orcid.org/0000-0002-9409-1876 Claudio Pinto http://orcid.org/0000-0001-8585-9495 Antonio Benedetti http://orcid.org/0000-0003-0280-4574 Marco Marzioni http://orcid.org/0000-0001-6014-6165 Luca Maroni http://orcid.org/0000-0003-4707-7374
Funding Agency and Grant Number
Corresponding Author	Luca Maroni, MD, PhD, Research Associate, Department of Gastroenterology and Hepatology, Università Politecnica delle Marche, Via Tronto 10A, Ancona 60126, Italy. l.maroni@univpm.it
Key Words	Cholangiocarcinoma; Cholangiocytes; Autophagy; Apoptosis; Chemoresistance; Autophagolysosome
Core Tip	This article reviews the occurrence and development of autophagy in cholangiocarcinoma and the corresponding therapeutic treatments. We analyse the role of autophagy in cancer, the link between autophagy and chemoresistance, and the use of autophagic markers in diagnostics. Overall, autophagy is a promising target in cancer therapy. Ongoing studies have the potential to unveil cancer-specific pathways amenable to therapeutic intervention.
Publish Date	2021-07-28 01:52
Citation	Ninfole E, Pinto C, Benedetti A, Marzioni M, Maroni L. Role of autophagy in cholangiocarcinoma: Pathophysiology and implications for therapy. World J Clin Cases 2021; 9(22): 6234-6243
URL	https://www.wjgnet.com/2307-8960/full/v9/i22/6234.htm
DOI	https://dx.doi.org/10.12998/wjcc.v9.i22.6234

Full Article (PDF)	WJCC-9-6234.pdf
Full Article (Word)	WJCC-9-6234.docx
Manuscript File	64426_Auto_Edited-ZMG.docx
Answering Reviewers	64426-Answering reviewers.pdf
Audio Core Tip	64426-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	64426-Conflict-of-interest statement.pdf
Copyright License Agreement	64426-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	64426-Language certificate.pdf
Peer-review Report	64426-Peer-review(s).pdf
Scientific Misconduct Check	64426-Bing-Wang JL-1.jpg
Scientific Misconduct Check	64426-Bing-Fan JR-2.png
Scientific Misconduct Check	64426-Scientific misconduct check.pdf
Scientific Editor Work List	64426-Scientific editor work list.pdf