Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	64580
Country	Italy

Received	2021-02-20 12:48
Peer-Review Started	2021-02-20 12:51
To Make the First Decision
Return for Revision	2021-03-15 04:44
Revised	2021-03-15 21:40
Second Decision	2021-05-08 07:46
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2021-05-08 08:53
Articles in Press	2021-05-08 08:53
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-05-18 21:32
Typeset the Manuscript	2021-06-04 06:30
Publish the Manuscript Online	2021-06-07 11:17

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Familial adenomatous polyposis and changes in the gut microbiota: New insights into colorectal cancer carcinogenesis
Manuscript Source	Invited Manuscript
All Author List	Antonio Biondi, Francesco Basile and Marco Vacante
ORCID	Author(s) ORCID Number Antonio Biondi http://orcid.org/0000-0002-9374-779X Francesco Basile http://orcid.org/0000-0001-6831-5840 Marco Vacante http://orcid.org/0000-0002-6815-5012
Funding Agency and Grant Number
Corresponding Author	Marco Vacante, MD, PhD, Academic Fellow, Doctor, Doctor, Research Fellow, Department of General Surgery and Medical-Surgical Specialties, University of Catania, Via Santa Sofia 78, Catania 95123, Italy. marcovacante@yahoo.it
Key Words	Familial adenomatous polyposis; Microbiota; Colorectal cancer; Polyps; Carcinogenesis; Bacteria
Core Tip	A number of studies demonstrated that gut microbiota dysbiosis could represent a key factor in colorectal carcinogenesis. The APCMin/+ mouse model has been extensively used to study the underlying mechanisms of colorectal carcinogenesis in familial adenomatous polyposis. Interventions aimed at improving dysbiosis, through administration of probiotics, prebiotics or antibiotics, could decrease colorectal cancer development in APC mutation carriers.
Publish Date	2021-06-07 11:17
Citation	Biondi A, Basile F, Vacante M. Familial adenomatous polyposis and changes in the gut microbiota: New insights into colorectal cancer carcinogenesis. World J Gastrointest Oncol 2021; 13(6): 495-508
URL	https://www.wjgnet.com/1948-5204/full/v13/i6/495.htm
DOI	https://dx.doi.org/10.4251/wjgo.v13.i6.495

Full Article (PDF)	WJGO-13-495.pdf
Full Article (Word)	WJGO-13-495.docx
Manuscript File	64580-Review-FilipodiaCL.docx
Answering Reviewers	64580-Answering reviewers.pdf
Audio Core Tip	64580-Audio core tip.aac
Conflict-of-Interest Disclosure Form	64580-Conflict-of-interest statement.pdf
Copyright License Agreement	64580-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	64580-Language certificate.pdf
Peer-review Report	64580-Peer-review(s).pdf
Scientific Misconduct Check	64580-Bing-Wang JL-1.jpg
Scientific Misconduct Check	64580-Scientific misconduct check.pdf
Scientific Editor Work List	64580-Scientific editor work list.pdf
CrossCheck Report	64580-CrossCheck report.pdf