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Articles Published Processes
4/6/2022 8:50:05 AM | Browse: 740 | Download: 2006
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Received |
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2021-02-27 02:07 |
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Peer-Review Started |
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2021-02-27 02:12 |
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First Decision by Editorial Office Director |
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2021-03-28 00:04 |
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Return for Revision |
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2021-03-28 00:04 |
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Revised |
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2021-04-10 22:37 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2021-09-02 02:54 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2021-09-02 07:31 |
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Articles in Press |
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2021-09-02 07:31 |
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Edit the Manuscript by Language Editor |
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2022-03-06 03:07 |
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Typeset the Manuscript |
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2022-03-30 08:01 |
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Publish the Manuscript Online |
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2022-04-06 08:50 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Engineering, Biomedical |
| Manuscript Type |
Basic Study |
| Article Title |
Syngeneic implantation of mouse hepatic progenitor cell-derived three-dimensional liver tissue with dense collagen fibrils
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Miho Tamai, Eijiro Adachi, Masaya Kawase and Yoh-ichi Tagawa |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Grants-in-Aid for Scientific Research (A) |
25242040 |
| Grants-in-Aid for Challenging Exploratory Research |
20K21520 |
| Grants-in-Aid for Early Career Scientists from the Japan Society for the Promotion of Science (JSPS) |
19K20655 |
| Grant-in-Aid for Scientific Research on Innovative Areas from the Ministry of Education, Culture, Sports, Science and Technology of Japan (MEXT) |
231190003 |
| Japan Agency for Medical Research and Development (AMED) |
20fk0310102 |
| Building of Consortia for the Development of Human Resources in Science and Technology, Ministry of Education, Culture, Sports, Science and Technology, Japan |
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| Corresponding Author |
Yoh-ichi Tagawa, DSc, Associate Professor, School of Life Science and Technology, Tokyo Institute of Technology, 4259 B51, Nagatsuta-cho, Midori-ku, Yokohama-shi 226-8501, Japan. ytagawa@bio.titech.ac.jp |
| Key Words |
Liver; Three-dimensional tissue culture; Hepatic progenitor cells; Angiogenesis; Biomimetic extracellular matrix |
| Core Tip |
Liver transplantation is a therapeutic procedure used to recover liver function in patients with irreversible liver failure; however, presently there is a shortage of transplant organs available. Hepatic stem and progenitor cells are expected to allow regenerative medicine to produce a cell source as an alternative to whole organs. The portal branch-ligated, hepatic lobe-derived hepatic progenitor cells multiplied in a bioreactor chamber to form liver organoid tissues comparable to liver lobules. These organoid tissues were implanted into syngeneic mice. This portal branch-ligated-derived hepatic progenitor cell line has the potential to proliferate, mature, and form implantable hepatic tissue. |
| Publish Date |
2022-04-06 08:50 |
| Citation |
Tamai M, Adachi E, Kawase M, Tagawa YI. Syngeneic implantation of mouse hepatic progenitor cell-derived three-dimensional liver tissue with dense collagen fibrils. World J Gastroenterol 2022; 28(14): 1444-1454 |
| URL |
https://www.wjgnet.com/1007-9327/full/v28/i14/1444.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v28.i14.1444 |
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