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Articles Published Processes
8/26/2014 4:37:00 PM | Browse: 1648 | Download: 1371
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Received |
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2013-10-19 11:14 |
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Peer-Review Started |
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2013-10-22 13:44 |
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To Make the First Decision |
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2014-01-16 08:22 |
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Return for Revision |
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2014-01-20 17:50 |
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Revised |
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2014-04-04 00:00 |
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Second Decision |
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2014-06-18 15:07 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2014-06-18 15:26 |
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Articles in Press |
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2014-06-18 15:50 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2014-07-02 11:50 |
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Publish the Manuscript Online |
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2014-07-15 13:33 |
| Category |
Oncology |
| Manuscript Type |
Autobiography |
| Article Title |
Novel diet-related mouse model of colon cancer parallels human colon cancer
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Anil R Prasad, Shilpa Prasad, Huy Nguyen, Alexander Facista, Cristy Lewis, Beryl Zaitlin, Harris Bernstein and Carol Bernstein |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Institutes of Health |
5 R01 CA119087 |
| Arizona Biomedical Research Commission |
0803 |
| Veterans Affairs Merit Review |
0142 |
| Southern Arizona Veterans Affairs Health Care System |
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| Corresponding Author |
Carol Bernstein, PhD, Department of Cellular and Molecular Medicine, College of Medicine, University of Arizona, 2639 E 4th Street, Tucson, AZ 85716, United States. bernstein324@yahoo.com |
| Key Words |
Diet; Deoxycholate; Mouse model; Colon cancer; Histology; Chlorogenic acid; 8-OH-dG; Beclin 1; Beta-catenin |
| Core Tip |
Mouse models of colon carcinogenesis are essential as platforms for trials of prevention and therapy. However, most previous rodent models of colon carcinogenesis lack an invasive phenotype and/or do not share several significant genetic events and histopathological features of human colon cancer. This new diet-related mouse model of colon cancer is unique in being closely parallel to human progression to sporadic colon cancer by measures of its histomorphology and its molecular profile. It also has a natural basis, using dietary deoxycholic acid, long thought to be a central causative agent in colon carcinogenesis. |
| Publish Date |
2014-07-15 13:33 |
| Citation |
Prasad AR, Prasad S, Nguyen H, Facista A, Lewis C, Zaitlin B, Bernstein H, Bernstein C. Novel diet-related mouse model of colon cancer parallels human colon cancer. World J Gastrointest Oncol 2014; 6(7): 225-243 |
| URL |
http://www.wjgnet.com/1948-5204/full/v6/i7/225.htm |
| DOI |
http://dx.doi.org/10.4251/wjgo.v6.i7.225 |
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