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8/26/2014 4:37:00 PM | Browse: 1486 | Download: 1060
Publication Name World Journal of Gastrointestinal Oncology
Manuscript ID 6472
Country/Territory United States
Received
2013-10-19 11:14
Peer-Review Started
2013-10-22 13:44
To Make the First Decision
2014-01-16 08:22
Return for Revision
2014-01-20 17:50
Revised
2014-04-04 00:00
Second Decision
2014-06-18 15:07
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-06-18 15:26
Articles in Press
2014-06-18 15:50
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2014-07-02 11:50
Publish the Manuscript Online
2014-07-15 13:33
ISSN 1948-5204 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Autobiography
Article Title Novel diet-related mouse model of colon cancer parallels human colon cancer
Manuscript Source Invited Manuscript
All Author List Anil R Prasad, Shilpa Prasad, Huy Nguyen, Alexander Facista, Cristy Lewis, Beryl Zaitlin, Harris Bernstein and Carol Bernstein
Funding Agency and Grant Number
Funding Agency Grant Number
National Institutes of Health 5 R01 CA119087
Arizona Biomedical Research Commission 0803
Veterans Affairs Merit Review 0142
Southern Arizona Veterans Affairs Health Care System
Corresponding Author Carol Bernstein, PhD, Department of Cellular and Molecular Medicine, College of Medicine, University of Arizona, 2639 E 4th Street, Tucson, AZ 85716, United States. bernstein324@yahoo.com
Key Words Diet; Deoxycholate; Mouse model; Colon cancer; Histology; Chlorogenic acid; 8-OH-dG; Beclin 1; Beta-catenin
Core Tip Mouse models of colon carcinogenesis are essential as platforms for trials of prevention and therapy. However, most previous rodent models of colon carcinogenesis lack an invasive phenotype and/or do not share several significant genetic events and histopathological features of human colon cancer. This new diet-related mouse model of colon cancer is unique in being closely parallel to human progression to sporadic colon cancer by measures of its histomorphology and its molecular profile. It also has a natural basis, using dietary deoxycholic acid, long thought to be a central causative agent in colon carcinogenesis.
Publish Date 2014-07-15 13:33
Citation Prasad AR, Prasad S, Nguyen H, Facista A, Lewis C, Zaitlin B, Bernstein H, Bernstein C. Novel diet-related mouse model of colon cancer parallels human colon cancer. World J Gastrointest Oncol 2014; 6(7): 225-243
URL http://www.wjgnet.com/1948-5204/full/v6/i7/225.htm
DOI http://dx.doi.org/10.4251/wjgo.v6.i7.225
Full Article (PDF) WJGO-6-225.pdf
Full Article (Word) WJGO-6-225.doc
Manuscript File 6472-Review.doc
Answering Reviewers 6472-Answering reviewers.pdf
Copyright License Agreement 6472-Copyright assignment.pdf
Peer-review Report 6472-Peer reviews.pdf
Scientific Misconduct Check 6472-CrossCheck.jpg
Scientific Editor Work List 6472-Scientific editor work list.pdf