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Articles Published Processes
7/7/2021 8:39:46 AM | Browse: 383 | Download: 922
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Received |
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2021-02-23 01:40 |
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Peer-Review Started |
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2021-02-23 01:42 |
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To Make the First Decision |
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Return for Revision |
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2021-03-28 16:06 |
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Revised |
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2021-04-03 20:02 |
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Second Decision |
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2021-05-25 09:51 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-05-25 11:34 |
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Articles in Press |
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2021-05-25 11:34 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2021-05-31 02:46 |
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Typeset the Manuscript |
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2021-06-19 09:35 |
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Publish the Manuscript Online |
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2021-07-07 08:39 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Systematic Reviews |
| Article Title |
Herb-induced liver injury: Systematic review and meta-analysis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Vinícius Remus Ballotin, Lucas Goldmann Bigarella, Ajacio Bandeira de Mello Brandão, Raul Angelo Balbinot, Silvana Sartori Balbinot and Jonathan Soldera |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Jonathan Soldera, MD, MSc, Associate Professor, Staff Physician, Department of Clinical Gastroenterology, Universidade de Caxias do Sul, Rua Francisco Getúlio Vargas, 1130, Caxias do Sul 95070-560, RS, Brazil. jonathansoldera@gmail.com |
| Key Words |
Herb-induced liver injury; Drug induced liver injury; Dietary supplements; Herbal hepatotoxicity; Liver transplantation |
| Core Tip |
The use of herbal supplements has been increasing in the last decades. Despite popular belief that natural products are harmless, these might cause herb-induced liver injury (HILI). This study aimed to identify herbal products associated with HILI. The search strategy retrieved 5918 references. In the final analysis, 446 references were included, with a total of 936 cases reported. We found 79 types of herbs related to HILI. Most of these patients had complete clinical recovery (82.8%). However, liver transplantation was necessary for 6.6% of these cases. Also, chronic liver disease and death were observed in 1.5% and 10.4%, respectively. |
| Publish Date |
2021-07-07 08:39 |
| Citation |
Ballotin VR, Bigarella LG, Brandão ABM, Balbinot RA, Balbinot SS, Soldera J. Herb-induced liver injury: Systematic review and meta-analysis. World J Clin Cases 2021; 9(20): 5490-5513 |
| URL |
https://www.wjgnet.com/2307-8960/full/v9/i20/5490.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v9.i20.5490 |
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