Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	64745
Country	Canada

Received	2021-02-23 02:12
Peer-Review Started	2021-02-23 02:16
To Make the First Decision
Return for Revision	2021-03-29 18:02
Revised	2021-04-14 13:34
Second Decision	2021-12-01 03:22
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2021-12-02 01:58
Articles in Press	2021-12-02 01:58
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-12-31 04:19
Publish the Manuscript Online	2022-01-11 00:11

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Proteasome regulators in pancreatic cancer
Manuscript Source	Invited Manuscript
All Author List	Nirosha J Murugan and Ioannis A Voutsadakis
ORCID	Author(s) ORCID Number Nirosha J Murugan http://orcid.org/0000-0001-7260-9956 Ioannis A Voutsadakis http://orcid.org/0000-0002-9301-5951
Funding Agency and Grant Number
Corresponding Author	Ioannis A Voutsadakis, MD, PhD, Associate Professor, Doctor, Doctor, Department of Medical Oncology, Sault Area Hospital, 750 Great Northern Road, Sault Sainte Marie P6A3T6, ON, Canada. ivoutsadakis@yahoo.com
Key Words	Pancreatic adenocarcinoma; Proteasome; Transcription factors; Regulation; Unfolded protein response; Cancer stem cells
Core Tip	Pancreatic adenocarcinoma is a gastrointestinal cancer with high incidence and bleak outcomes. The molecular pathways involved in the pathogenesis of the disease have been increasingly clarified in recent years. This article reviews the role of proteostasis regulation through the proteasome in pancreatic cancer. Major molecular pathways affected in pancreatic cancer closely interconnect with regulators of the proteasome.
Publish Date	2022-01-11 00:11
Citation	Murugan NJ, Voutsadakis IA. Proteasome regulators in pancreatic cancer. World J Gastrointest Oncol 2022; 14(1): 38-54
URL	https://www.wjgnet.com/1948-5204/full/v14/i1/38.htm
DOI	https://dx.doi.org/10.4251/wjgo.v14.i1.38

Full Article (PDF)	WJGO-14-38.pdf
Full Article (Word)	WJGO-14-38.docx
Manuscript File	64745_Auto_Edited.docx
Answering Reviewers	64745-Answering reviewers.pdf
Audio Core Tip	64745-Audio core tip.wma
Conflict-of-Interest Disclosure Form	64745-Conflict-of-interest_statement.pdf
Copyright License Agreement	64745-Copyright license agreement.pdf
Peer-review Report	64745-Peer-review(s).pdf
Scientific Misconduct Check	64745-Bing-Wang JL-1.jpg
Scientific Misconduct Check	64745-Bing-Wu YXJ-2.png
Scientific Editor Work List	64745-Scientific editor work list.pdf
CrossCheck Report	64745-CrossCheck report.pdf